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WormBase Tree Display for Variation: WBVar00094143

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Name Class

WBVar00094143NamePublic_nameok3062
Other_nameF18A1.6b.2:c.453_890delinsGAAAACATTGACAATGGATGATTG
CE04406:p.Ser156_Lys294delinsTer
F18A1.6a.1:c.444_881delinsGAAAACATTGACAATGGATGATTG
CE27977:p.Ser159_Lys297delinsTer
F18A1.6b.1:c.453_890delinsGAAAACATTGACAATGGATGATTG
HGVSgCHROMOSOME_II:g.7661078_7661563delinsCAATCATCCATTGTCAATGTTTTC
Sequence_detailsSMapS_parentSequenceF18A1
Flanking_sequencesgtcatcattccaaatgcatcttcatactttgtacttgttgtagcagattcagtcatatat
Mapping_targetF18A1
Type_of_mutationInsertionCAATCATCCATTGTCAATGTTTTC
Deletion
PCR_productok3062_external
ok3062_internal
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00032941
Component_of_genotypeWBGenotype00000077
WBGenotype00000078
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00017547
TranscriptF18A1.6b.2 (11)
F18A1.6a.1 (11)
F18A1.6b.1 (11)
IsolationMutagenEMS
DescriptionPhenotypeWBPhenotype:0000016Paper_evidenceWBPaper00044611
Curator_confirmedWBPerson557
Remarkalfa-1(ok3062) mutants were more sensitive to aldicarb induced paralysis compared to wild type worms (Figure 2B). Authors suggest that alfa-1(ok3062) mutants may haveimpaired inhibitory GABAergic signaling.Paper_evidenceWBPaper00044611
Curator_confirmedWBPerson557
Phenotype_assayTreatmentWorms treated with 1mM aldicarb.Paper_evidenceWBPaper00044611
Curator_confirmedWBPerson557
WBPhenotype:0000636Paper_evidenceWBPaper00044611
Curator_confirmedWBPerson557
Remarkalfa-1(ok3062) mutants have increased neurodegeneration in motor neurons during adulthood. Authors call this age-dependent neurodegeneration.Paper_evidenceWBPaper00044611
Curator_confirmedWBPerson557
WBPhenotype:0000643Paper_evidenceWBPaper00044611
Curator_confirmedWBPerson557
Remarkalfa-1(ok3062) mutants display motility defects causing paralysis in adulthood. Authors call this an age-dependent motility defect.Paper_evidenceWBPaper00044611
Curator_confirmedWBPerson557
WBPhenotype:0000876Paper_evidenceWBPaper00044611
Curator_confirmedWBPerson557
Remarkalfa-1(ok3062) mutants were more sensitive to osmotic stress associated lethality compared to N2 worms.Paper_evidenceWBPaper00044611
Curator_confirmedWBPerson557
Phenotype_assayTreatmentWorms were placed on 400 mM NaCl.Paper_evidenceWBPaper00044611
Curator_confirmedWBPerson557
Disease_infoModels_diseaseDOID:332
Models_disease_in_annotationWBDOannot00001028
ReferenceWBPaper00044611
RemarkSequenced by the C. elegans Gene Knockout ConsortiumPaper_evidenceWBPaper00041807
MethodKO_consortium_allele