WormBase Tree Display for Variation: WBVar00093858

WBVar00093858 Evidence: Paper_evidence: WBPaper00039858
  Name: Public_name: ok2759
    HGVSg: CHROMOSOME_III:g.5173267_5173924del
  Sequence_details: SMap: S_parent: Sequence: K10D2
    Flanking_sequences: ttaaaatctcagcgggagtttgatcaaatt cattgggaaagacgaaccgaataataggta
    Mapping_target: K10D2
    Type_of_mutation: Deletion
    PCR_product: ok2759_external
      ok2759_internal
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00037175
    Laboratory: RB
    Person: WBPerson46
    KO_consortium_allele
    Status: Live
  Affects: Gene: WBGene00019629
      WBGene00019630
      WBGene00019631
    Transcript: K10D2.4.1 VEP_consequence: transcript_ablation
        VEP_impact: HIGH
        Intron_number: 2/3
        Exon_number: 1-4/4
      K10D2.5.1 VEP_consequence: 3_prime_UTR_variant
        VEP_impact: MODIFIER
        cDNA_position: 458-?
        Exon_number: 5/5
      K10D2.3.1 VEP_consequence: 5_prime_UTR_variant
        VEP_impact: MODIFIER
        cDNA_position: ?-3
        Exon_number: 1/14
  Isolation: Mutagen: EMS
  Description: Phenotype: WBPhenotype:0000684 Paper_evidence: WBPaper00039858
        Curator_confirmed: WBPerson712
        Remark: Sterile hermaphrodites had severely reduced germlines containing a small number of early germ cells and no evidence of undergoing a mitotic-to-meiotic transition. Paper_evidence: WBPaper00039858
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: unc-42; lon-1 Paper_evidence: WBPaper00039858
              Curator_confirmed: WBPerson712
      WBPhenotype:0000688 Paper_evidence: WBPaper00039858
        Curator_confirmed: WBPerson712
        Remark: ok2759 deletion homozygotes hatch and develop into sterile (Ste) adults. Paper_evidence: WBPaper00039858
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: unc-42; lon-1 Paper_evidence: WBPaper00039858
              Curator_confirmed: WBPerson712
      WBPhenotype:0000691 Paper_evidence: WBPaper00039858
        Curator_confirmed: WBPerson712
        Remark: The gonads of emb-1(ok2759) homozygotes failed to completely develop. The gonads exhibited little evidence of either spermatogenesis or oogenesis, and the arms remained linear and failed to reflex toward the dorsal side. Paper_evidence: WBPaper00039858
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: unc-42; lon-1 Paper_evidence: WBPaper00039858
              Curator_confirmed: WBPerson712
      WBPhenotype:0000697 Paper_evidence: WBPaper00039858
        Curator_confirmed: WBPerson712
        Remark: ok2759 deletion homozygotes hatch and develop into adults with a protruding vulva (Pvl) phenotype. Paper_evidence: WBPaper00039858
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: unc-42; lon-1 Paper_evidence: WBPaper00039858
              Curator_confirmed: WBPerson712
      WBPhenotype:0000823 Paper_evidence: WBPaper00039858
        Curator_confirmed: WBPerson712
        Remark: Both male and hermaphrodites exhibit reduced germlines. Paper_evidence: WBPaper00039858
            Curator_confirmed: WBPerson712
        Phenotype_assay: Genotype: unc-42; lon-1 Paper_evidence: WBPaper00039858
              Curator_confirmed: WBPerson712
  Reference: WBPaper00039858
  Remark: Sequenced by the C. elegans Gene Knockout Consortium Paper_evidence: WBPaper00041807
  Method: KO_consortium_allele