WormBase Tree Display for Variation: WBVar00091604
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| WBVar00091604 | Name | Public_name | ok306 | |||||
|---|---|---|---|---|---|---|---|---|
| Sequence_details | Mapping_target | R04A9 | ||||||
| PCR_product | OK306_external | |||||||
| OK306_internal | ||||||||
| SeqStatus | Pending_curation | |||||||
| Variation_type | Allele | |||||||
| Origin | Species | Caenorhabditis elegans | ||||||
| Strain | WBStrain00024077 | |||||||
| WBStrain00031365 | ||||||||
| Laboratory | RB | |||||||
| Person | WBPerson46 | |||||||
| KO_consortium_allele | ||||||||
| Status | Live | |||||||
| Affects | Gene | WBGene00002060 | ||||||
| Interactor | WBInteraction000008570 | |||||||
| WBInteraction000008583 | ||||||||
| WBInteraction000504399 | ||||||||
| WBInteraction000504400 | ||||||||
| WBInteraction000536876 | ||||||||
| WBInteraction000536969 | ||||||||
| Genetics | Mapping_data | In_multi_point | 4432 | |||||
| Description | Phenotype | WBPhenotype:0000061 | Paper_evidence | WBPaper00029008 | ||||
| Curator_confirmed | WBPerson557 | |||||||
| WBPhenotype:0000121 | Paper_evidence | WBPaper00029008 | ||||||
| Curator_confirmed | WBPerson557 | |||||||
| Remark | Reduced rate of accumulation of newly synthesized proteins. | Paper_evidence | WBPaper00029008 | |||||
| Curator_confirmed | WBPerson557 | |||||||
| WBPhenotype:0001236 | Paper_evidence | WBPaper00043917 | ||||||
| Curator_confirmed | WBPerson2987 | |||||||
| Remark | "To further affirm this conclusion we took advantage of the ife-2(ok306) deletion [68] mutant, in which somatic translation is reduced. This mutant should mimic the effect of translation associated RNAis if the observed inhibitory effect is mitigated through a reduction of protein translation. Paraquat induced hsp-6 expression was not reduced, but rather increased in ok306 mutant animals, indicating that a moderate inhibition of translation is not sufficient to prevent hsp-6 induction by paraquat." (Figure S4) | Paper_evidence | WBPaper00043917 | |||||
| Curator_confirmed | WBPerson2987 | |||||||
| Affected_by | Molecule | WBMol:00002747 | Paper_evidence | WBPaper00043917 | ||||
| Curator_confirmed | WBPerson2987 | |||||||
| Phenotype_assay | Genotype | zcIs13 [Phsp-6::GFP] | Paper_evidence | WBPaper00043917 | ||||
| Curator_confirmed | WBPerson2987 | |||||||
| WBPhenotype:0001273 | Paper_evidence | WBPaper00029008 | ||||||
| Curator_confirmed | WBPerson557 | |||||||
| Remark | increased thermotolerance | Paper_evidence | WBPaper00029008 | |||||
| Curator_confirmed | WBPerson557 | |||||||
| Phenotype_assay | Treatment | thermotolerance measured as survival time at 35 C | Paper_evidence | WBPaper00029008 | ||||
| Curator_confirmed | WBPerson557 | |||||||
| Reference | WBPaper00029008 | |||||||
| WBPaper00019485 | ||||||||
| WBPaper00043917 | ||||||||
| Remark | Sequenced by the Vancouver Gene Knockout Lab (part of the C. elegans Gene Knockout Consortium) | |||||||
| Method | KO_consortium_allele |
