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WormBase Tree Display for Variation: WBVar00091504

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Name Class

WBVar00091504NamePublic_nameok195
Sequence_detailsMapping_targetK07B1
PCR_productOK195_external
OK195_internal
SeqStatusPending_curation
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005332
WBStrain00031433
LaboratoryRB
PersonWBPerson46
KO_consortium_allele
StatusLive
AffectsGeneWBGene00006729
DescriptionPhenotypeWBPhenotype:0000138Paper_evidenceWBPaper00040122
Curator_confirmedWBPerson557
RemarkTotal triglyceride levels in ucp4 homogenates were increased 35 percent compared with N2.Paper_evidenceWBPaper00040122
Curator_confirmedWBPerson557
WBPhenotype:0001184Paper_evidenceWBPaper00040122
Curator_confirmedWBPerson557
RemarkAnimals have significantly increased lipid accumulation when compared with control. Assayed via Nile Red accumulation.Paper_evidenceWBPaper00040122
Curator_confirmedWBPerson557
WBPhenotype:0002143Paper_evidenceWBPaper00040122
Curator_confirmedWBPerson557
Remarkucp4 animals have a selective failure of complex II-mediated mitochondrial respiration and show a decrease in succinate uptake.Paper_evidenceWBPaper00040122
Curator_confirmedWBPerson557
WBPhenotype:0002401Paper_evidenceWBPaper00040122
Curator_confirmedWBPerson557
RemarkGas chromatography/mass spectrometry analyses in adult worm homogenates revealed that ucp4 worms exhibited a significant accumulation of the fatty acids palmitate (C16:0), oleate (C18:1n9), and laurate (C12:0), but not stearate or linoleate, compared with N2.Paper_evidenceWBPaper00040122
Curator_confirmedWBPerson557
ReferenceWBPaper00040122
RemarkSequenced by the Vancouver Gene Knockout Lab (part of the C. elegans Gene Knockout Consortium)
MethodKO_consortium_allele