WormBase Tree Display for Variation: WBVar00091504
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WBVar00091504 | Name | Public_name | ok195 | ||||
---|---|---|---|---|---|---|---|
Sequence_details | Mapping_target | K07B1 | |||||
PCR_product | OK195_external | ||||||
OK195_internal | |||||||
SeqStatus | Pending_curation | ||||||
Variation_type | Allele | ||||||
Origin | Species | Caenorhabditis elegans | |||||
Strain | WBStrain00005332 | ||||||
WBStrain00031433 | |||||||
Laboratory | RB | ||||||
Person | WBPerson46 | ||||||
KO_consortium_allele | |||||||
Status | Live | ||||||
Affects | Gene | WBGene00006729 | |||||
Description | Phenotype | WBPhenotype:0000138 | Paper_evidence | WBPaper00040122 | |||
Curator_confirmed | WBPerson557 | ||||||
Remark | Total triglyceride levels in ucp4 homogenates were increased 35 percent compared with N2. | Paper_evidence | WBPaper00040122 | ||||
Curator_confirmed | WBPerson557 | ||||||
WBPhenotype:0001184 | Paper_evidence | WBPaper00040122 | |||||
Curator_confirmed | WBPerson557 | ||||||
Remark | Animals have significantly increased lipid accumulation when compared with control. Assayed via Nile Red accumulation. | Paper_evidence | WBPaper00040122 | ||||
Curator_confirmed | WBPerson557 | ||||||
WBPhenotype:0002143 | Paper_evidence | WBPaper00040122 | |||||
Curator_confirmed | WBPerson557 | ||||||
Remark | ucp4 animals have a selective failure of complex II-mediated mitochondrial respiration and show a decrease in succinate uptake. | Paper_evidence | WBPaper00040122 | ||||
Curator_confirmed | WBPerson557 | ||||||
WBPhenotype:0002401 | Paper_evidence | WBPaper00040122 | |||||
Curator_confirmed | WBPerson557 | ||||||
Remark | Gas chromatography/mass spectrometry analyses in adult worm homogenates revealed that ucp4 worms exhibited a significant accumulation of the fatty acids palmitate (C16:0), oleate (C18:1n9), and laurate (C12:0), but not stearate or linoleate, compared with N2. | Paper_evidence | WBPaper00040122 | ||||
Curator_confirmed | WBPerson557 | ||||||
Reference | WBPaper00040122 | ||||||
Remark | Sequenced by the Vancouver Gene Knockout Lab (part of the C. elegans Gene Knockout Consortium) | ||||||
Method | KO_consortium_allele |