WormBase Tree Display for Variation: WBVar00090302
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WBVar00090302 | Name | Public_name | n1936 | ||||||
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Sequence_details | SeqStatus | Pending_curation | |||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00005220 | ||||||||
Laboratory | MT | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00003848 | |||||||
Interactor | WBInteraction000503644 | ||||||||
WBInteraction000569528 | |||||||||
Genetics | Mapping_data | In_multi_point | 2059 | ||||||
2060 | |||||||||
2061 | |||||||||
2062 | |||||||||
Description | Phenotype | WBPhenotype:0000264 | Paper_evidence | WBPaper00001786 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Variable defects in responses to cAMP (Data not shown) | Paper_evidence | WBPaper00001786 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0000302 | Paper_evidence | WBPaper00001786 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Defective in chemotaxis to benzaldehyde at all tested dilutions | Paper_evidence | WBPaper00001786 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Life_stage | WBls:0000041 | PATO:0000460 | Paper_evidence | WBPaper00001786 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Treatment | Benzaldehyde dilutions range from 1:10 to 1:1000 | Paper_evidence | WBPaper00001786 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0000304 | Paper_evidence | WBPaper00001786 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Defective in chemotaxis to isoamyl alcohol at all tested dilutions | Paper_evidence | WBPaper00001786 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Life_stage | WBls:0000041 | PATO:0000460 | Paper_evidence | WBPaper00001786 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Treatment | Isoamyl alcohol dilutions range from 1:10 to 1:1000 | Paper_evidence | WBPaper00001786 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0000738 | Paper_evidence | WBPaper00062280 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Loss of odr-1 eliminates ascr#3 response (Figure 1D). To identify the site of odr-1 action, we used strains that narrowly expressed the wild type ODR-1 protein in the background of the loss-of-function mutant odr-1(n1936) (Krzyzanowski et al., 2016). We focused on the latter four neuronal pairs because loss of ASG does not affect ascr#3 response (Figure 1B), while ASI is involved in ascr#10response and therefore could not be tested in this paradigm (Aprison and Ruvinsky, 2017). Expression of ODR-1 in ASJ, ASK, or AWC did not rescue the odr-1(n1936) mutant phenotype (Figure 1E). In contrast, expression in AWB robustly rescued odr1(n1936) (Figure 1F), indicating that ODR-1 acts in AWB with respect to ascr#3 response. | Paper_evidence | WBPaper00062280 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00005125 | Paper_evidence | WBPaper00062280 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBMol:00005104 | Paper_evidence | WBPaper00062280 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001085 | Paper_evidence | WBPaper00001786 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Defective in chemotaxis to 2-butanone at 1:100 and 1:1000 dilutions | Paper_evidence | WBPaper00001786 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
EQ_annotations | Life_stage | WBls:0000041 | PATO:0000460 | Paper_evidence | WBPaper00001786 | ||||
Curator_confirmed | WBPerson2021 | ||||||||
Phenotype_assay | Treatment | 2-butanone dilutions range from 1:10 to 1:1000 | Paper_evidence | WBPaper00001786 | |||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0001438 | Paper_evidence | WBPaper00031959 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals are defective in chemotaxis to ammonium acetate as an odorant, compared to wild-type. | Paper_evidence | WBPaper00031959 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00002790 | Paper_evidence | WBPaper00031959 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | For the odorant assay, a droplet of NH4Ac (10 mL, 7.5 M) was suspended from the lid of the plate. | Paper_evidence | WBPaper00031959 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0001442 | Paper_evidence | WBPaper00001786 | |||||||
Curator_confirmed | WBPerson2021 | ||||||||
Remark | Variable defects in responses to sodium acetate (Data not shown) | Paper_evidence | WBPaper00001786 | ||||||
Curator_confirmed | WBPerson2021 | ||||||||
WBPhenotype:0001454 | Paper_evidence | WBPaper00043948 | |||||||
Curator_confirmed | WBPerson557 | ||||||||
Remark | Hypersensitive response to quinine. | Paper_evidence | WBPaper00043948 | ||||||
Curator_confirmed | WBPerson557 | ||||||||
Phenotype_assay | Treatment | Worms grown on 1 mM quinine. | Paper_evidence | WBPaper00043948 | |||||
Curator_confirmed | WBPerson557 | ||||||||
WBPhenotype:0001484 | Paper_evidence | WBPaper00031959 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals did not show a reduction in chemotaxis to ammonium acetate in the soluble chemotaxis assay; however in the odorant chemotaxis assay, animals showed a significant reduction in chemotaxis compared to wild-type animals. | Paper_evidence | WBPaper00031959 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00002790 | Paper_evidence | WBPaper00031959 | |||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_assay | Treatment | Animals were tested in both soluble and odorant chemotaxis assays. For the soluble assay, radial gradients of NH4Ac were established by diffusion in the agar. For the odorant assay, a droplet of NH4Ac (10 mL, 7.5 M) was suspended from the lid of the plate. | Paper_evidence | WBPaper00031959 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0002055 | Paper_evidence | WBPaper00036207 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | odr-1(n1936) mutant worms had a severe reduction in the density of photocurrents. | Paper_evidence | WBPaper00036207 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Phenotype_not_observed (14) | |||||||||
Reference | WBPaper00006052 | ||||||||
WBPaper00001786 | |||||||||
WBPaper00031959 | |||||||||
WBPaper00028386 | |||||||||
WBPaper00023490 | |||||||||
WBPaper00036207 | |||||||||
WBPaper00003680 | |||||||||
WBPaper00043948 | |||||||||
WBPaper00064927 | |||||||||
WBPaper00062280 | |||||||||
Method | Allele |