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WormBase Tree Display for Variation: WBVar00090010

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Name Class

WBVar00090010EvidencePaper_evidenceWBPaper00003764
NamePublic_namen1186
Other_name (27)
HGVSgCHROMOSOME_IV:g.10339043G>A
Sequence_detailsSMapS_parentSequenceK11E8
Flanking_sequencesgagagggaagccagaatttgcagaaaactcagcatccaaatattgttagactacacgaca
Mapping_targetK11E8
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00003764
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00026985
LaboratoryMT
StatusLive
Linked_toWBVar00089555
AffectsGeneWBGene00006779
Transcript (17)
InteractorWBInteraction000052105
WBInteraction000501679
WBInteraction000501730
GeneticsInterpolated_map_positionIV4.57623
DescriptionPhenotypeWBPhenotype:0000016Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Remark% animals paralyzed after 60 min on 1mM aldicarb was significantly higher than % N2 animals paralyzed.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003650Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0007833PATO:0001549Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0000180Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkThe intensity of GFP::SNB-1 axonal fluorescence was significantly lower than that observed in wild-type.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005190PATO:0000460Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Phenotype_assayGenotypejuIs1Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0000655Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkRate and amplitude of endogenous IPSCs were significantly decreased compared to wild-type although the shape of the average IPSC was identical to wild-type.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0001316Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkMuscimol activated current was significantly less than that observed for wild type animals.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0001319Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkRate of endogenous IPSCs were decreased 77% compared to wild-type.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0001320Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkThe amplitude of endogenous IPSCs were decreased 36% compared to wild-type controls.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0001512Paper_evidenceWBPaper00029404
Curator_confirmedWBPerson712
RemarkAnimals express str-2::GFP in both AWC cells, e.g. both AWC neurons are AWC on (n=216).Paper_evidenceWBPaper00029404
Curator_confirmedWBPerson712
PenetranceHighPaper_evidenceWBPaper00029404
Curator_confirmedWBPerson712
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00029404
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005672PATO:0000460Paper_evidenceWBPaper00029404
Curator_confirmedWBPerson712
WBbt:0005832PATO:0000460Paper_evidenceWBPaper00029404
Curator_confirmedWBPerson712
WBbt:0005833PATO:0000460Paper_evidenceWBPaper00029404
Curator_confirmedWBPerson712
Phenotype_assayGenotypestr-2::GFPPaper_evidenceWBPaper00029404
Curator_confirmedWBPerson712
WBPhenotype:0001661Paper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
RemarkMutants are defective in str-2 asymmetryPaper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0005672PATO:0000460Paper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
WBPhenotype:0001685Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkNumber of post-synaptic GFP-tagged UNC-49 GABAAR::GFP puncta was decreased compared to wild typePaper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Phenotype_assayGenotypeGFP-tagged GABAARPaper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000616Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkThe alignment of the pre (RFP-tagged RAB-3) and post synaptic (GFP-tagged UNC-49) components was unaltered.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005190PATO:0000460Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Phenotype_assayGenotypeoxIs22; nuIs283Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0000656Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkRate and amplitude of endogenous EPSCs were comparable to wild-type.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0000847Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkThe density of GFP::SNB-1 puncta in GABAergic and cholinergic axons was not significantly different from wild-type.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Phenotype_assayGenotypenuIs152 or juIs1Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0001013Paper_evidenceWBPaper00005370
Curator_confirmedWBPerson712
RemarkAnimals were found to have no Esp killing response to PA14.Paper_evidenceWBPaper00005370
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00005370
Curator_confirmedWBPerson712
Phenotype_assayTreatmentApproximately 25 L4-stage worms were placed on each of three agar plates with PA14 lawns under standard slow killing (SK) assay conditions. Survival was assayed after 30 hours.Paper_evidenceWBPaper00005370
Curator_confirmedWBPerson712
WBPhenotype:0001660Paper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
Remarkgcy-5 was asymmetrically expressed only in ASER in unc-43 mutantsPaper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00003760
Curator_confirmedWBPerson2021
WBPhenotype:0002199Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
Remark"However, neither crh-1 mutants that lacked a C. elegans CREB homolog (Nishida et al., 2011) nor unc-43 mutants that lacked the C. elegans CaMKII ortholog (Reiner et al., 1999) showed a severe defect in the variable calcium response of AFD (Figure S2B)."Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0005662PATO:0000460Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
Phenotype_assayGenotypenjIs24[gcy-8p::GCaMP3, gcy-8p::TagRFP] (I); Parent strain: IK1286Paper_evidenceWBPaper00049050
Curator_confirmedWBPerson2987
ReferenceWBPaper00031872
WBPaper00003760
WBPaper00005370
WBPaper00029404
WBPaper00049050
MethodSubstitution_allele