WormBase Tree Display for Variation: WBVar00089924

WBVar00089924 Name: Public_name: n1051
    Other_name: CE44782:p.Trp69Ter
      C16B8.1.1:c.206G>A
    HGVSg: CHROMOSOME_X:g.3958946G>A
  Sequence_details: SMap: S_parent: Sequence: C16B8
    Flanking_sequences: tggcaaacatcgactacctctcgttcacat gaatgctgttggaattgtaataaaaacata
    Mapping_target: C16B8
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00024383
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026934
    Laboratory: MT
    Status: Live
  Affects: Gene: WBGene00003007
    Transcript: C16B8.1.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: C16B8.1.1:c.206G>A
        HGVSp: CE44782:p.Trp69Ter
        cDNA_position: 214
        CDS_position: 206
        Protein_position: 69
        Exon_number: 3/14
        Codon_change: tGg/tAg
        Amino_acid_change: W/*
    Interactor: WBInteraction000524380
      WBInteraction000534754
  Genetics: Interpolated_map_position: X -8.87019
  Description: Phenotype: WBPhenotype:0000220 Paper_evidence: WBPaper00024693
        Curator_confirmed: WBPerson2987
        Remark: Vulva cell fate specification was abnormal as indicated by the expression patterns of the cdh-3::CFP and ceh-2::YFP transgenes (Figure 5) Paper_evidence: WBPaper00024693
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0004448 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004447 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004436 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004435 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004434 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004433 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004432 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
      WBPhenotype:0000695 Paper_evidence: WBPaper00024693
        Curator_confirmed: WBPerson2987
        Remark: Figure 5 Paper_evidence: WBPaper00024693
            Curator_confirmed: WBPerson2987
      WBPhenotype:0000700 Paper_evidence: WBPaper00000762
        Curator_confirmed: WBPerson2021
        Remark: Single protrusion posterior to the vulva. Paper_evidence: WBPaper00000762
            Curator_confirmed: WBPerson2021
        Recessive: Paper_evidence: WBPaper00000762
          Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000057 PATO:0000460 Paper_evidence: WBPaper00000762
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Heat_sensitive: Paper_evidence: WBPaper00000762
              Curator_confirmed: WBPerson2021
        Maternal
      WBPhenotype:0002011 Paper_evidence: WBPaper00024693
        Curator_confirmed: WBPerson2987
        Remark: Figure 5 Paper_evidence: WBPaper00024693
            Curator_confirmed: WBPerson2987
      WBPhenotype:0002193 Paper_evidence: WBPaper00024693
        Curator_confirmed: WBPerson2987
        Remark: "In wild type, vulA cells arise from the posterior daughter of P7.p (P7.pp). However, in lin-17(-), lin-18(-), and in double mutants, vulA cells most commonly arose from the anterior daughter of P7.p (P7.pa). This pattern of vulA specification suggests a reversal in the P7.p lineage at the first round of cell division." (Figure 5, Table 3) Paper_evidence: WBPaper00024693
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0004434 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004435 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004432 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004433 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004436 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004447 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
            WBbt:0004448 PATO:0000460 Paper_evidence: WBPaper00024693
                Curator_confirmed: WBPerson2987
    Phenotype_not_observed: WBPhenotype:0001235 Paper_evidence: WBPaper00004436
        Curator_confirmed: WBPerson2987
        Remark: Animals exhibited wild type V5 cell division polarity (Table 2) Paper_evidence: WBPaper00004436
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0004890 PATO:0000460 Paper_evidence: WBPaper00004436
                Curator_confirmed: WBPerson2987
            WBbt:0004876 PATO:0000460 Paper_evidence: WBPaper00004436
                Curator_confirmed: WBPerson2987
            WBbt:0004250 PATO:0000460 Paper_evidence: WBPaper00004436
                Curator_confirmed: WBPerson2987
            WBbt:0007446 PATO:0000460 Paper_evidence: WBPaper00004436
                Curator_confirmed: WBPerson2987
            WBbt:0004246 PATO:0000460 Paper_evidence: WBPaper00004436
                Curator_confirmed: WBPerson2987
            WBbt:0007463 PATO:0000460 Paper_evidence: WBPaper00004436
                Curator_confirmed: WBPerson2987
          Life_stage: WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00004436
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Temperature: 25 Paper_evidence: WBPaper00004436
              Curator_confirmed: WBPerson2987
  Reference: WBPaper00004436
    WBPaper00000762
    WBPaper00024693
    WBPaper00023511
  Method: Substitution_allele