WormBase Tree Display for Variation: WBVar00088949

WBVar00088949 Evidence: Person_evidence: WBPerson315
      WBPerson3294
  Name: Public_name: mg366
    Other_name: CE30163:p.Asn268LysfsTer46
      CE17214:p.Asn268LysfsTer46
      T07A9.5d.1:c.185_186insAAAAAAACAGGCACTTTATCGAA
      CE48636:p.Asn62LysfsTer46
      T07A9.5c.1:c.185_186insAAAAAAACAGGCACTTTATCGAA
      T07A9.5b.1:c.803_804insAAAAAAACAGGCACTTTATCGAA
      CE49054:p.Asn62LysfsTer46
      T07A9.5a.1:c.803_804insAAAAAAACAGGCACTTTATCGAA
    HGVSg: CHROMOSOME_IV:g.418238_418239insTTCGATAAAGTGCCTGTTTTTTT
  Sequence_details: SMap: S_parent: Sequence: T07A9
    Flanking_sequences: ataaaacttcggaacatatggggcattcgaata ttcgataaaaggcattgaaattgcatgaatt
    Mapping_target: T07A9
    Type_of_mutation: Insertion: ttcgataaagtgcctgttttttt Person_evidence: WBPerson3294
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain (18)
    Laboratory: GR
    Status: Live
  Affects: Gene: WBGene00001332
    Transcript: T07A9.5b.1 VEP_consequence: frameshift_variant
        VEP_impact: HIGH
        HGVSc: T07A9.5b.1:c.803_804insAAAAAAACAGGCACTTTATCGAA
        HGVSp: CE30163:p.Asn268LysfsTer46
        cDNA_position: 810-811
        CDS_position: 803-804
        Protein_position: 268
        Exon_number: 7/14
        Codon_change: aat/aaAAAAAAACAGGCACTTTATCGAAt
        Amino_acid_change: N/KKKQALYRX
      T07A9.5d.1 VEP_consequence: frameshift_variant
        VEP_impact: HIGH
        HGVSc: T07A9.5d.1:c.185_186insAAAAAAACAGGCACTTTATCGAA
        HGVSp: CE48636:p.Asn62LysfsTer46
        cDNA_position: 185-186
        CDS_position: 185-186
        Protein_position: 62
        Exon_number: 3/9
        Codon_change: aat/aaAAAAAAACAGGCACTTTATCGAAt
        Amino_acid_change: N/KKKQALYRX
      T07A9.5c.1 VEP_consequence: frameshift_variant
        VEP_impact: HIGH
        HGVSc: T07A9.5c.1:c.185_186insAAAAAAACAGGCACTTTATCGAA
        HGVSp: CE49054:p.Asn62LysfsTer46
        cDNA_position: 185-186
        CDS_position: 185-186
        Protein_position: 62
        Exon_number: 3/5
        Codon_change: aat/aaAAAAAAACAGGCACTTTATCGAAt
        Amino_acid_change: N/KKKQALYRX
      T07A9.5a.1 VEP_consequence: frameshift_variant
        VEP_impact: HIGH
        HGVSc: T07A9.5a.1:c.803_804insAAAAAAACAGGCACTTTATCGAA
        HGVSp: CE17214:p.Asn268LysfsTer46
        cDNA_position: 810-811
        CDS_position: 803-804
        Protein_position: 268
        Exon_number: 7/10
        Codon_change: aat/aaAAAAAAACAGGCACTTTATCGAAt
        Amino_acid_change: N/KKKQALYRX
    Interactor (252)
  Isolation: Mutagen: EMS
    Forward_genetics: screen for enhanced RNAi
  Genetics: Interpolated_map_position: IV -26.023
  Description: Phenotype (15)
    Phenotype_not_observed: WBPhenotype:0001759 Paper_evidence: WBPaper00031962
          WBPaper00035199
        Curator_confirmed: WBPerson712
        Remark: Levels of 21U-RNA, from Nothern blot or from qRT-PRC, were comparable to that of wild-type. Paper_evidence: WBPaper00031962
            Curator_confirmed: WBPerson712
          Animals retain the ability to express this class of small regulatory RNAs. Paper_evidence: WBPaper00035199
            Curator_confirmed: WBPerson712
        EQ_annotations: GO_term: GO:0034585 PATO:0000460 Paper_evidence: WBPaper00031962
                Curator_confirmed: WBPerson712
      WBPhenotype:0001778 Paper_evidence: WBPaper00032049
        Curator_confirmed: WBPerson712
        Remark: Of animals exposed to dsRNA targeting nuclear-localized lin-15b, 95 4% exhibited a Muv phenotype. In addition, a decrease in both lin-15b and lin-15a pre-mRNA abundance was observed. Paper_evidence: WBPaper00032049
            Curator_confirmed: WBPerson712
        Phenotype_assay: Treatment: Animals were fed bacteria expressing dsRNAs. Paper_evidence: WBPaper00032049
              Curator_confirmed: WBPerson712
      WBPhenotype:0001779 Paper_evidence: WBPaper00035199
        Curator_confirmed: WBPerson712
        Remark: Animals retain the ability to express this class of small regulatory RNAs. Paper_evidence: WBPaper00035199
            Curator_confirmed: WBPerson712
  Reference (17)
  Remark
  Method: Insertion_allele