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WormBase Tree Display for Variation: WBVar00088858

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Name Class

WBVar00088858EvidencePaper_evidenceWBPaper00003738
NamePublic_namemd1971
Other_name (48)
HGVSgCHROMOSOME_V:g.36741C>T
Sequence_detailsSMapS_parentSequenceB0348
Flanking_sequencesggtcagcggattcttccgctggatgggcttaggcaggatatcggcatatttcgctgaggt
Mapping_targetB0348
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00003738
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00033391
LaboratoryRM
StatusLive
AffectsGeneWBGene00001177
Transcript (24)
InteractorWBInteraction000501272
WBInteraction000536162
WBInteraction000536163
GeneticsInterpolated_map_positionV-20.0202
DescriptionPhenotypeWBPhenotype:0000017Paper_evidenceWBPaper00035198
WBPaper00038528
WBPaper00031535
Curator_confirmedWBPerson712
WBPerson2987
RemarkFigure 4GPaper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003650Paper_evidenceWBPaper00035198
WBPaper00031535
Curator_confirmedWBPerson712
WBPerson2987
WBPhenotype:0000420Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
RemarkFigure S2CPaper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00004019Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
WBPhenotype:0000523Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
Remark"Addition of VPA to either egl-8 PLCβ mutants or UNC-13(+) animals did not further decrease levels of ACh release (Figure 4, C and G), whereas UNC-13(+) animals responded to VPA the same as wild type (Figure 4E). Thus, both egl-8 mutant animals and UNC-13(+) animals are resistant to the effects of VPA on ACh release."Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00004943Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
WBMol:00003650Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
WBPhenotype:0000631Paper_evidenceWBPaper00035198
Curator_confirmedWBPerson712
RemarkAnimals exhibit anterior convulsions when treated with pentylenetetrazole(PTZ).Paper_evidenceWBPaper00035198
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004251Paper_evidenceWBPaper00035198
Curator_confirmedWBPerson712
WBPhenotype:0000743Paper_evidenceWBPaper00046355
Curator_confirmedWBPerson51
RemarkFigure 1GPaper_evidenceWBPaper00046355
Curator_confirmedWBPerson51
EQ_annotationsGO_termGO:0016246PATO:0000460Paper_evidenceWBPaper00046355
Curator_confirmedWBPerson51
WBPhenotype:0001258Paper_evidenceWBPaper00046355
Curator_confirmedWBPerson51
RemarkFigure 1GPaper_evidenceWBPaper00046355
Curator_confirmedWBPerson51
EQ_annotationsGO_termGO:0016246PATO:0000460Paper_evidenceWBPaper00046355
Curator_confirmedWBPerson51
WBPhenotype:0001905Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
Remark"Defects in DAG production (PLCβ EGL-8) and DAG signaling [UNC-13(+) animals] caused fewer eggs to be laid, and this was not further reduced by exposure to VPA (Figure 6, B and D)."Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000523Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
Remark"Interestingly, VPA still increases muscle sensitivity to levamisole in both egl-8 mutant animals and UNC-13(+) animals (Supplemental Figure 2, B and C), suggesting that VPA effects on the muscle are independent of DAG signaling via EGL-8 and UNC-13 in neurons."Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
"PMA caused wild-type, egl-8 PLCβ mutants, and UNC-13(+) animals to be hypersensitive to the paralytic effects of aldicarb, and this sensitivity was not decreased by exposure to VPA (Figure 4, B, F, and H)..."Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00004019Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
WBMol:00004943Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
WBMol:00003650Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
WBMol:00000950Paper_evidenceWBPaper00031535
Curator_confirmedWBPerson2987
ReferenceWBPaper00038528
WBPaper00035198
WBPaper00003738
WBPaper00031535
WBPaper00025484
WBPaper00046355
WBPaper00065340
MethodSubstitution_allele