WormBase Tree Display for Variation: WBVar00088858
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WBVar00088858 | Evidence | Paper_evidence | WBPaper00003738 | ||||||
---|---|---|---|---|---|---|---|---|---|
Name | Public_name | md1971 | |||||||
Other_name (48) | |||||||||
HGVSg | CHROMOSOME_V:g.36741C>T | ||||||||
Sequence_details | SMap | S_parent | Sequence | B0348 | |||||
Flanking_sequences | ggtcagcggattcttccgctggatgggctt | aggcaggatatcggcatatttcgctgaggt | |||||||
Mapping_target | B0348 | ||||||||
Type_of_mutation | Substitution | c | t | Paper_evidence | WBPaper00003738 | ||||
SeqStatus | Sequenced | ||||||||
Variation_type | Allele | ||||||||
Origin | Species | Caenorhabditis elegans | |||||||
Strain | WBStrain00033391 | ||||||||
Laboratory | RM | ||||||||
Status | Live | ||||||||
Affects | Gene | WBGene00001177 | |||||||
Transcript (24) | |||||||||
Interactor | WBInteraction000501272 | ||||||||
WBInteraction000536162 | |||||||||
WBInteraction000536163 | |||||||||
Genetics | Interpolated_map_position | V | -20.0202 | ||||||
Description | Phenotype | WBPhenotype:0000017 | Paper_evidence | WBPaper00035198 | |||||
WBPaper00038528 | |||||||||
WBPaper00031535 | |||||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPerson2987 | |||||||||
Remark | Figure 4G | Paper_evidence | WBPaper00031535 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Affected_by | Molecule | WBMol:00003650 | Paper_evidence | WBPaper00035198 | |||||
WBPaper00031535 | |||||||||
Curator_confirmed | WBPerson712 | ||||||||
WBPerson2987 | |||||||||
WBPhenotype:0000420 | Paper_evidence | WBPaper00031535 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | Figure S2C | Paper_evidence | WBPaper00031535 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Affected_by | Molecule | WBMol:00004019 | Paper_evidence | WBPaper00031535 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000523 | Paper_evidence | WBPaper00031535 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Addition of VPA to either egl-8 PLCβ mutants or UNC-13(+) animals did not further decrease levels of ACh release (Figure 4, C and G), whereas UNC-13(+) animals responded to VPA the same as wild type (Figure 4E). Thus, both egl-8 mutant animals and UNC-13(+) animals are resistant to the effects of VPA on ACh release." | Paper_evidence | WBPaper00031535 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Affected_by | Molecule | WBMol:00004943 | Paper_evidence | WBPaper00031535 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBMol:00003650 | Paper_evidence | WBPaper00031535 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBPhenotype:0000631 | Paper_evidence | WBPaper00035198 | |||||||
Curator_confirmed | WBPerson712 | ||||||||
Remark | Animals exhibit anterior convulsions when treated with pentylenetetrazole(PTZ). | Paper_evidence | WBPaper00035198 | ||||||
Curator_confirmed | WBPerson712 | ||||||||
Affected_by | Molecule | WBMol:00004251 | Paper_evidence | WBPaper00035198 | |||||
Curator_confirmed | WBPerson712 | ||||||||
WBPhenotype:0000743 | Paper_evidence | WBPaper00046355 | |||||||
Curator_confirmed | WBPerson51 | ||||||||
Remark | Figure 1G | Paper_evidence | WBPaper00046355 | ||||||
Curator_confirmed | WBPerson51 | ||||||||
EQ_annotations | GO_term | GO:0016246 | PATO:0000460 | Paper_evidence | WBPaper00046355 | ||||
Curator_confirmed | WBPerson51 | ||||||||
WBPhenotype:0001258 | Paper_evidence | WBPaper00046355 | |||||||
Curator_confirmed | WBPerson51 | ||||||||
Remark | Figure 1G | Paper_evidence | WBPaper00046355 | ||||||
Curator_confirmed | WBPerson51 | ||||||||
EQ_annotations | GO_term | GO:0016246 | PATO:0000460 | Paper_evidence | WBPaper00046355 | ||||
Curator_confirmed | WBPerson51 | ||||||||
WBPhenotype:0001905 | Paper_evidence | WBPaper00031535 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Defects in DAG production (PLCβ EGL-8) and DAG signaling [UNC-13(+) animals] caused fewer eggs to be laid, and this was not further reduced by exposure to VPA (Figure 6, B and D)." | Paper_evidence | WBPaper00031535 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Phenotype_not_observed | WBPhenotype:0000523 | Paper_evidence | WBPaper00031535 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
Remark | "Interestingly, VPA still increases muscle sensitivity to levamisole in both egl-8 mutant animals and UNC-13(+) animals (Supplemental Figure 2, B and C), suggesting that VPA effects on the muscle are independent of DAG signaling via EGL-8 and UNC-13 in neurons." | Paper_evidence | WBPaper00031535 | ||||||
Curator_confirmed | WBPerson2987 | ||||||||
"PMA caused wild-type, egl-8 PLCβ mutants, and UNC-13(+) animals to be hypersensitive to the paralytic effects of aldicarb, and this sensitivity was not decreased by exposure to VPA (Figure 4, B, F, and H)..." | Paper_evidence | WBPaper00031535 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Affected_by | Molecule | WBMol:00004019 | Paper_evidence | WBPaper00031535 | |||||
Curator_confirmed | WBPerson2987 | ||||||||
WBMol:00004943 | Paper_evidence | WBPaper00031535 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBMol:00003650 | Paper_evidence | WBPaper00031535 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
WBMol:00000950 | Paper_evidence | WBPaper00031535 | |||||||
Curator_confirmed | WBPerson2987 | ||||||||
Reference | WBPaper00038528 | ||||||||
WBPaper00035198 | |||||||||
WBPaper00003738 | |||||||||
WBPaper00031535 | |||||||||
WBPaper00025484 | |||||||||
WBPaper00046355 | |||||||||
WBPaper00065340 | |||||||||
Method | Substitution_allele |