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WormBase Tree Display for Variation: WBVar00088273

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Name Class

WBVar00088273EvidencePaper_evidenceWBPaper00031930
NamePublic_namekr105
Sequence_detailsMapping_targetF09E8
Type_of_mutationInsertion
SeqStatusPending_curation
Variation_typeAllele
Transposon_insertionMos1
OriginSpeciesCaenorhabditis elegans
LaboratoryEN
StatusLive
AffectsGeneWBGene00002974
DescriptionPhenotypeWBPhenotype:0000421Paper_evidenceWBPaper00031930
Curator_confirmedWBPerson712
RemarkAnimals were less sensitive to levamisole; EC50 = 223.Paper_evidenceWBPaper00031930
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004019Paper_evidenceWBPaper00031930
Curator_confirmedWBPerson712
WBPhenotype:0001783Paper_evidenceWBPaper00031930
Curator_confirmedWBPerson712
RemarkThe single-channel conductance of the lev-1;lev-10 mutant was 26.9 0.7 pS (n=3), which was less than the mean 30.3 0.4 pS of the lev-10 control animals (P=0.019, df=34). At 10 M levamisole, the mean closed times of receptors lacking LEV-1 subunits were not significantly different from control animals.Paper_evidenceWBPaper00031930
Curator_confirmedWBPerson712
EQ_annotationsGO_termGO:0022834PATO:0000460Paper_evidenceWBPaper00031930
Curator_confirmedWBPerson712
Phenotype_assayGenotypelev-10Paper_evidenceWBPaper00031930
Curator_confirmedWBPerson712
ReferenceWBPaper00031930
MethodMos_insertion