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WormBase Tree Display for Variation: WBVar00087782

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WBVar00087782	Evidence	Paper_evidence	WBPaper00003351
	Name	Public_name	hc81
		Other_name	CE06618:p.Gln116Ter
			ZK524.1.1:c.346C>T
		HGVSg	CHROMOSOME_I:g.7455441C>T
	Sequence_details	SMap	S_parent	Sequence	ZK524
		Flanking_sequences	tgtcttttgatattgtttggggtatccgcg	agactcttcatgatatgttttcacaagtat
		Mapping_target	ZK524
		Type_of_mutation	Substitution	c	t	Paper_evidence	WBPaper00003351
		SeqStatus	Sequenced
	Variation_type	Allele
	Origin	Species	Caenorhabditis elegans
		Laboratory	BA
		Status	Live
	Affects	Gene	WBGene00004958
		Transcript	ZK524.1.1	VEP_consequence	stop_gained
				VEP_impact	HIGH
				HGVSc	ZK524.1.1:c.346C>T
				HGVSp	CE06618:p.Gln116Ter
				cDNA_position	400
				CDS_position	346
				Protein_position	116
				Exon_number	3/10
				Codon_change	Cag/Tag
				Amino_acid_change	Q/*
	Genetics	Interpolated_map_position	I	2.09248
	Description	Phenotype	WBPhenotype:0000186	Paper_evidence	WBPaper00001075
				Curator_confirmed	WBPerson2021
				Remark	Hermaphrodites lay fewer oocytes than wild type	Paper_evidence	WBPaper00001075
						Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001075
					Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000057	PATO:0000460	Paper_evidence	WBPaper00001075
								Curator_confirmed	WBPerson2021
				Phenotype_assay	Temperature	16C	Paper_evidence	WBPaper00001075
							Curator_confirmed	WBPerson2021
			WBPhenotype:0000290	Paper_evidence	WBPaper00001075
				Curator_confirmed	WBPerson2021
				Remark	No sperm or haploid nuclei are observed after DAPI staining of the adult reproductive tract of hermaphrodites	Paper_evidence	WBPaper00001075
						Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001075
					Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000057	PATO:0000460	Paper_evidence	WBPaper00001075
								Curator_confirmed	WBPerson2021
				Phenotype_assay	Temperature	16C	Paper_evidence	WBPaper00001075
							Curator_confirmed	WBPerson2021
			WBPhenotype:0000357	Paper_evidence	WBPaper00001075
					WBPaper00001612
				Curator_confirmed	WBPerson2021
					WBPerson725
				Remark	Hermaphrodites are self-sterile because they make defective sperm. Oocytes are cross fertile with wild type sperm.	Paper_evidence	WBPaper00001612
						Curator_confirmed	WBPerson725
				Recessive	Paper_evidence	WBPaper00001075
					Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000057	PATO:0000460	Paper_evidence	WBPaper00001075
								Curator_confirmed	WBPerson2021
				Phenotype_assay	Temperature	16C	Paper_evidence	WBPaper00001075
							Curator_confirmed	WBPerson2021
			WBPhenotype:0000417	Paper_evidence	WBPaper00001612
				Curator_confirmed	WBPerson725
				Remark	Specific to only spermatogenesis	Paper_evidence	WBPaper00001612
						Curator_confirmed	WBPerson725
				EQ_annotations	Anatomy_term	WBbt:0006799	PATO:0000460	Paper_evidence	WBPaper00001612
								Curator_confirmed	WBPerson725
					GO_term	GO:0007283	PATO:0000460	Paper_evidence	WBPaper00001612
								Curator_confirmed	WBPerson725
			WBPhenotype:0000692	Paper_evidence	WBPaper00001612
				Curator_confirmed	WBPerson725
				Remark	spe-4 males are cross-sterile	Paper_evidence	WBPaper00001612
						Curator_confirmed	WBPerson725
			WBPhenotype:0000981	Paper_evidence	WBPaper00001075
				Curator_confirmed	WBPerson2021
				Remark	Spermatocytes differ from wild type because they have completed the nuclear events of meiosis and have four haploid nuclei in syncytium	Paper_evidence	WBPaper00001075
						Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001075
					Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000056	PATO:0000460	Paper_evidence	WBPaper00001075
								Curator_confirmed	WBPerson2021
				Phenotype_assay	Temperature	16C	Paper_evidence	WBPaper00001075
							Curator_confirmed	WBPerson2021
			WBPhenotype:0000982	Paper_evidence	WBPaper00001075
				Curator_confirmed	WBPerson2021
				Remark	Spermatogenesis in males arrests during development of spermatids from spermatocytes	Paper_evidence	WBPaper00001075
						Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001075
					Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000056	PATO:0000460	Paper_evidence	WBPaper00001075
								Curator_confirmed	WBPerson2021
				Phenotype_assay	Temperature	16C	Paper_evidence	WBPaper00001075
							Curator_confirmed	WBPerson2021
			WBPhenotype:0001360	Paper_evidence	WBPaper00001075
				Curator_confirmed	WBPerson2021
				Recessive	Paper_evidence	WBPaper00001075
					Curator_confirmed	WBPerson2021
				EQ_annotations	Life_stage	WBls:0000057	PATO:0000460	Paper_evidence	WBPaper00001075
								Curator_confirmed	WBPerson2021
				Phenotype_assay	Temperature	16C	Paper_evidence	WBPaper00001075
							Curator_confirmed	WBPerson2021
			WBPhenotype:0001683	Paper_evidence	WBPaper00001612
				Curator_confirmed	WBPerson725
				Remark	meiosis is completed but all four nuclei are in one arrested, abnormal spermatocyte. This is a completely penetrant phenotype and self-sterility is 100%.	Paper_evidence	WBPaper00001612
						Curator_confirmed	WBPerson725
				EQ_annotations	GO_term	GO:0007283	PATO:0000460	Paper_evidence	WBPaper00001612
								Curator_confirmed	WBPerson725
			WBPhenotype:0002386	Paper_evidence	WBPaper00001612
				Curator_confirmed	WBPerson725
				Remark	Fibrous bodies are not associated with membranous organelles.	Paper_evidence	WBPaper00001612
						Curator_confirmed	WBPerson725
	Reference	WBPaper00001612
		WBPaper00001075
		WBPaper00021640
	Method	Substitution_allele