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WormBase Tree Display for Variation: WBVar00000664

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Name Class

WBVar00000664EvidencePaper_evidenceWBPaper00032072
NamePublic_namebz301
Other_nameT01C8.7.1:c.446C>T
CE39109:p.Ala149Val
HGVSgCHROMOSOME_X:g.16806262G>A
Sequence_detailsSMapS_parentSequenceF41G4
Flanking_sequencescttactgagcttttttatttccagacactgaccttttccagcaattacgctttgtaattt
Mapping_targetF41G4
Type_of_mutationSubstitutionctPaper_evidenceWBPaper00032072
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryZB
StatusLive
AffectsGeneWBGene00003168
TranscriptT01C8.7.1 (12)
GeneticsInterpolated_map_positionX24.0629
DescriptionPhenotype_not_observedWBPhenotype:0000179Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
RemarkNeurotoxicity was not conferred in the absence of Ismec-10(d). In the presence of lsmec-10(d) however, touch cell neurons died, only AVM and PVM survived. The mutation acted semi-dominantly to enhance neuronal loss in lsmec-10(d) animals.Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
Semi_dominantPaper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005237PATO:0000460Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
Life_stageWBls:0000038PATO:0000460Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
Phenotype_assayGenotypemec-10(+) or zdIs5[pmec-4GFP] I; bzIs67[mec-10(d)]Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
WBPhenotype:0000315Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
RemarkTouch responses were normal. In the presence of lsmec-10(d), touch cell responses were impaired.Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
Semi_dominantPaper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005237PATO:0000460Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
Genotypemec-10(+) or zdIs5[pmec-4GFP] I; bzIs67[mec-10(d)]Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
WBPhenotype:0001397Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
RemarkNeurotoxicity was not conferred in the absence of Ismec-10(d). In the presence of lsmec-10(d) however, touch cell neurons died, only AVM and PVM survived. The mutation acted semi-dominantly to enhance neuronal loss in lsmec-10(d) animals. Onset of necrosis may be after L1 stage.Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
Semi_dominantPaper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005237PATO:0000460Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
Life_stageWBls:0000038PATO:0000460Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
Phenotype_assayTemperature20Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
Genotypemec-10(+) or zdIs5[pmec-4GFP] I; bzIs67[mec-10(d)]Paper_evidenceWBPaper00032072
Curator_confirmedWBPerson712
ReferenceWBPaper00032072
MethodSubstitution_allele