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WormBase Tree Display for Variation: WBVar00000425

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Name Class

WBVar00000425EvidencePaper_evidenceWBPaper00003831
NamePublic_nameb1026
Other_nameCE22368:p.Gly493Glu
CE49356:p.Gly414Glu
T11F8.3b.1:c.1241G>A
T11F8.3a.1:c.1478G>A
HGVSgCHROMOSOME_IV:g.5471646G>A
Sequence_detailsSMapS_parentSequenceT11F8
Flanking_sequencestgattcttacagctccatctccaagcgctggatttccatctgcacaatgagcggaatgtt
Mapping_targetT11F8
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00003831
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
LaboratoryDH
StatusLive
AffectsGeneWBGene00004374
TranscriptT11F8.3b.1 (12)
T11F8.3a.1 (12)
GeneticsInterpolated_map_positionIV1.68705
DescriptionPhenotypeWBPhenotype:0000050Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
RemarkMost embryos failed to hatch, viability 23%. Escapers proceeded through normal larval development and produced animals with similar defects.Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
WBPhenotype:0000154Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
RemarkAnimals had reduced embryo production.Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
WBPhenotype:0000436Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
RemarkAnimals lacked defined RME-2 localization at the oocyte plasma membrane.Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006797PATO:0000460Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
WBbt:0005175PATO:0000460Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
WBPhenotype:0000668Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
RemarkA high percentage of gonad arms contained one endomitotic-like oocyte proximal to the spermatheca.Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
WBPhenotype:0000978Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
RemarkTime-lapse video recordings of ovulations indicated frequent failure of spermathecal dilation as well as common premature closure, which breaks oocytes into fragments as they pass.Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
WBPhenotype:0001260Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
RemarkOocytes were morphologically wild-type although slightly small and devoid of yolk.Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006797PATO:0000460Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
WBPhenotype:0001762Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
RemarkYP170::GFP protein flourescence, a full length yolk protein fusion, was devoid in oocytes.Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
Phenotype_assayGenotypeYP170::GFPPaper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000120Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
RemarkAnimals exhibited abundant cytoplasmic immunostaining with both anti-RME-2 antisera.Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006797PATO:0000460Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
WBPhenotype:0000812Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
RemarkAnimals exhibited normal germ line morphology.Paper_evidenceWBPaper00003831
Curator_confirmedWBPerson712
ReferenceWBPaper00003831
MethodSubstitution_allele