WormBase Tree Display for Variation: WBVar00000017

WBVar00000017 Name: Public_name: ad472
    Other_name: ad472cs
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00005467
    Laboratory: DA
    Status: Live
  Affects: Gene: WBGene00004011
    Interactor: WBInteraction000500284
      WBInteraction000502396
      WBInteraction000502397
  Genetics: Mapping_data: In_2_point: 5219
        6172
        6173
        6174
        6176
      In_multi_point: 1845
        1875
        2428
        2429
        2430
        2431
        2432
  Description: Phenotype: WBPhenotype:0000081 Paper_evidence: WBPaper00001709
        Curator_confirmed: WBPerson2021
        Remark: Weakly cold sensitive: More larvae passed the L1 block at 25 C than at 15 C or 20 C. Paper_evidence: WBPaper00001709
            Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000024 PATO:0000460 Paper_evidence: WBPaper00001709
                Curator_confirmed: WBPerson2021
        Temperature_sensitive: Cold_sensitive: Paper_evidence: WBPaper00001709
              Curator_confirmed: WBPerson2021
        Phenotype_assay: Temperature: 15, 20, 25 Paper_evidence: WBPaper00001709
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000181 Paper_evidence: WBPaper00031671
        Curator_confirmed: WBPerson2021
        Remark: 21% of the dorsal NSM processes are absent Paper_evidence: WBPaper00031671
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00031671
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0003666 PATO:0000460 Paper_evidence: WBPaper00031671
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: zdIs13 [ tph-1p::GFP] Paper_evidence: WBPaper00031671
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000384 Paper_evidence: WBPaper00031671
        Curator_confirmed: WBPerson2021
        Remark: 45% of NSM neurons exhibit anterior misguidance defects in pha-2 mutants Paper_evidence: WBPaper00031671
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00031671
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0003666 PATO:0000460 Paper_evidence: WBPaper00031671
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: zdIs13 [ tph-1p::GFP] Paper_evidence: WBPaper00031671
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000491 Paper_evidence: WBPaper00001709
        Curator_confirmed: WBPerson2021
        Remark: pha-2 worms have nuclei in the isthmus (which are never found in wild-type) Paper_evidence: WBPaper00001709
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0003734 PATO:0000460 Paper_evidence: WBPaper00001709
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000547 Paper_evidence: WBPaper00001709
        Curator_confirmed: WBPerson2021
        EQ_annotations: Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00001709
                Curator_confirmed: WBPerson2021
      WBPhenotype:0000633 Paper_evidence: WBPaper00031671
        Curator_confirmed: WBPerson2021
        Remark: 27% of the neurons show other defects such as multiple branching and misplaced cell bodies Paper_evidence: WBPaper00031671
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00031671
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0003666 PATO:0000460 Paper_evidence: WBPaper00031671
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: zdIs13 [ tph-1p::GFP] Paper_evidence: WBPaper00031671
              Curator_confirmed: WBPerson2021
      WBPhenotype:0000901 Paper_evidence: WBPaper00040002
        Curator_confirmed: WBPerson712
        Remark: gland projections display severe abnormalities, like those seen in sma-1 mutants; the gland phenotype becomes more severe as pha-2 animals develop, with late larvae and adults having grossly swollen gland projections; the defects in the gland projections are largely confined to the posterior pharynx Paper_evidence: WBPaper00040002
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005788 PATO:0000460 Paper_evidence: WBPaper00040002
                Curator_confirmed: WBPerson712
          Life_stage: WBls:0000041 PATO:0000460 Paper_evidence: WBPaper00040002
                Curator_confirmed: WBPerson712
      WBPhenotype:0001310 Paper_evidence: WBPaper00031671
        Curator_confirmed: WBPerson2021
        Remark: 27% of the neurons show other defects such as multiple branching and misplaced cell bodies Paper_evidence: WBPaper00031671
            Curator_confirmed: WBPerson2021
        Variation_effect: Hypomorph_reduction_of_function: Paper_evidence: WBPaper00031671
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0003666 PATO:0000460 Paper_evidence: WBPaper00031671
                Curator_confirmed: WBPerson2021
        Phenotype_assay: Genotype: zdIs13 [ tph-1p::GFP] Paper_evidence: WBPaper00031671
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001525 Paper_evidence: WBPaper00001709
        Curator_confirmed: WBPerson2021
        Remark: Terminal bulb is smaller in size and the grinder is mispositioned Paper_evidence: WBPaper00001709
            Curator_confirmed: WBPerson2021
        EQ_annotations: Anatomy_term: WBbt:0003732 PATO:0000460 Paper_evidence: WBPaper00001709
                Curator_confirmed: WBPerson2021
  Reference: WBPaper00040002
    WBPaper00031671
    WBPaper00001709
    WBPaper00019606
  Method: Allele