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WormBase Tree Display for Variation: WBVar00089919

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Name Class

WBVar00089919EvidencePaper_evidenceWBPaper00001366
NamePublic_namen1046
Other_nameZK792.6.1:c.38G>A
CE03827:p.Gly13Glu
HGVSgCHROMOSOME_IV:g.11691040C>T
Sequence_detailsSMapS_parentSequenceZK792
Flanking_sequencesagtacaagcttgtggtagttggagatggagagttggtaaatcagcactcaccattcaact
Mapping_targetZK792
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00001366
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (16)
Component_of_genotypeWBGenotype00000028
WBGenotype00000029
WBGenotype00000030
WBGenotype00000038
LaboratoryMT
StatusLive
AffectsGeneWBGene00002335
TranscriptZK792.6.1 (12)
Interactor (69)
IsolationMutagenEMSPaper_evidenceWBPaper00001366
Genetics (2)
DescriptionPhenotype (15)
Phenotype_not_observedWBPhenotype:0000039Paper_evidenceWBPaper00002935
Curator_confirmedWBPerson712
Remarkn1046 did not affect life span.Paper_evidenceWBPaper00002935
Curator_confirmedWBPerson712
WBPhenotype:0000050Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Remark1.6% progeny (n=613) fail to hatch, compared to 1.3% progeny of wild type (n=525) that failed to hatch.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAll strains were grown at 20C.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
WBPhenotype:0000054Paper_evidenceWBPaper00026863
WBPaper00005344
Curator_confirmedWBPerson712
WBPerson2987
Remark1.3% animals die during larval development (n=603), compared to 0% (n=518) wild type animals larval lethality.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00026863
WBPaper00005344
Curator_confirmedWBPerson712
WBPerson2987
Phenotype_assayTreatmentAll strains were grown at 20C.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
WBPhenotype:0000099Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
RemarkThe let-6(n1046) mutation did not result in any animals with the '0 P11.p' phenotype (P11 adopts a P12 fate) or the '2 P11.p' phenotype (P12 adopts a P11 fate)Paper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00005344
Curator_confirmedWBPerson2987
WBPhenotype:0000147Paper_evidenceWBPaper00040181
Curator_confirmedWBPerson712
RemarkShort-term starvation was able to deplete the intestinal lipids of let-60(n1046 gf) worms.Paper_evidenceWBPaper00040181
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00040181
Curator_confirmedWBPerson712
WBPhenotype:0000245Paper_evidenceWBPaper00036021
Curator_confirmedWBPerson712
WBPhenotype:0000424Paper_evidenceWBPaper00031318
Curator_confirmedWBPerson712
RemarkMutants have a diphosphorylated activated form of MPK-1 (dpMPK-1) accumulation pattern indistinguishable from wild type.Paper_evidenceWBPaper00031318
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00031318
Curator_confirmedWBPerson712
WBPhenotype:0000640Paper_evidenceWBPaper00026707
Curator_confirmedWBPerson712
PenetranceLow<1% (n=191)Paper_evidenceWBPaper00026707
Curator_confirmedWBPerson712
WBPhenotype:0000688Paper_evidenceWBPaper00026863
WBPaper00031318
Curator_confirmedWBPerson712
Remark100% animals produced progeny (n=42).Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Mutants are fertile at 15, 20, and 25 deg C.Paper_evidenceWBPaper00031318
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00026863
WBPaper00031318
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAll strains were grown at 20C.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
WBPhenotype:0000698Paper_evidenceWBPaper00026863
WBPaper00005344
Curator_confirmedWBPerson712
WBPerson2987
Remark0% animals (n=46) are aberrant in induction of VPCs.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00026863
WBPaper00005344
Curator_confirmedWBPerson712
WBPerson2987
Phenotype_assayTreatmentAll strains were grown at 20C.Paper_evidenceWBPaper00026863
Curator_confirmedWBPerson712
WBPhenotype:0000905Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004538Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005672PATO:0000460Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBbt:0005671PATO:0000460Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBPhenotype:0001024Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkMale gross morphology wildtypePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Semi_dominantPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001084Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005670PATO:0000460Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBPhenotype:0001278Paper_evidenceWBPaper00057074
Curator_confirmedWBPerson712
Remarkneurons did not show a loss in unc-25::GFP expressionPaper_evidenceWBPaper00057074
Curator_confirmedWBPerson712
ImageWBPicture0000014913Paper_evidenceWBPaper00057074
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005027PATO:0000460Paper_evidenceWBPaper00057074
Curator_confirmedWBPerson712
WBbt:0005021PATO:0000460Paper_evidenceWBPaper00057074
Curator_confirmedWBPerson712
WBPhenotype:0001668Paper_evidenceWBPaper00031914
Curator_confirmedWBPerson712
RemarkAnimals 24 or 48 hours post-L4 stage did not exhibit a significant increase in oocytes compared to wild-type animals.Paper_evidenceWBPaper00031914
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00031914
Curator_confirmedWBPerson712
Disease_infoModels_diseaseDOID:162
DOID:0080690
Models_disease_in_annotationWBDOannot00000779
WBDOannot00000854
Reference (73)
MethodSubstitution_allele