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WormBase Tree Display for Variation: WBVar00143951

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Name Class

WBVar00143951EvidencePaper_evidenceWBPaper00004623
NamePublic_namee1372
Other_nameB0412.2.1:c.369+1G>A
HGVSgCHROMOSOME_III:g.812434G>A
Sequence_detailsSMapS_parentSequenceB0412
Flanking_sequencesaatgatttggaaagaagcgatattcttcagtatcgtttggtttttttttaaaaagaatcc
Mapping_targetB0412
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00004623
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00000063
WBStrain00004310
WBStrain00005597
WBStrain00006202
WBStrain00006360
WBStrain00022755
WBStrain00023548
WBStrain00026329
WBStrain00026330
WBStrain00026331
WBStrain00035147
WBStrain00035150
WBStrain00050822
WBStrain00050823
WBStrain00050824
WBStrain00050825
WBStrain00050852
WBStrain00051573
LaboratoryCB
StatusLive
AffectsGeneWBGene00000903
TranscriptB0412.2.1VEP_consequencesplice_donor_variant
VEP_impactHIGH
HGVScB0412.2.1:c.369+1G>A
Intron_number3/6
Interactor (86)
IsolationMutagenEMSPaper_evidenceWBPaper00004623
GeneticsInterpolated_map_positionIII-25.7993
Mapping_dataIn_2_point273
422
423
2720
2721
4974
6130
In_multi_point (25)
In_pos_neg_data1585
1592
DescriptionPhenotype (34)
Phenotype_not_observedWBPhenotype:0000039Paper_evidenceWBPaper00031688
WBPaper00038374
Curator_confirmedWBPerson712
WBPerson2987
Remark"In our hands, mutations in the upstream components of the TGF-b pathway such as daf-7 and daf-14 enhance dauer formation but do not significantly extend lifespan (Table S1 and Figure S4)."Paper_evidenceWBPaper00038374
Curator_confirmedWBPerson2987
Phenotype_assayGenotypedaf-2(e1370)Paper_evidenceWBPaper00038374
Curator_confirmedWBPerson2987
WBPhenotype:0000061Paper_evidenceWBPaper00001837
Curator_confirmedWBPerson712
RemarkLifespans of adults were not noticeable different from wild type. Lifespans were examined when grown continuously at 15 deg C, or when shifted from 15 to 20 deg C and from 15 to 25 deg C as L4 animals.Paper_evidenceWBPaper00001837
Curator_confirmedWBPerson712
WBPhenotype:0000306Paper_evidenceWBPaper00031997
Curator_confirmedWBPerson712
Remarklag-2::GFP was expressed at the same levels as in dauer larvae induced by dauer pheromone, starvation or by Daf-c mutations in the three parallel pathways. There was no detectable changes in expression level between newly induced or older dauers.Paper_evidenceWBPaper00031997
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005118PATO:0000460Paper_evidenceWBPaper00031997
Curator_confirmedWBPerson712
Life_stageWBls:0000032PATO:0000460Paper_evidenceWBPaper00031997
Curator_confirmedWBPerson712
Phenotype_assayGenotypeqIs56 [lag-2::GFP , unc-119(+)]Paper_evidenceWBPaper00031997
Curator_confirmedWBPerson712
WBPhenotype:0000631Paper_evidenceWBPaper00036280
Curator_confirmedWBPerson712
RemarkLife span was lengthened in response to trehalose, similar to N2 animals under the same conditions.Paper_evidenceWBPaper00036280
Curator_confirmedWBPerson712
WBPhenotype:0000671Paper_evidenceWBPaper00004599
Curator_confirmedWBPerson2987
Remarkdaf-7(e1372) mutant animals were not resistant to copper (Figure 1A)Paper_evidenceWBPaper00004599
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002862Paper_evidenceWBPaper00004599
Curator_confirmedWBPerson2987
WBPhenotype:0000717Paper_evidenceWBPaper00035610
Curator_confirmedWBPerson2021
Remarkdaf-3 transcripts were not affected in daf-7 mutantsPaper_evidenceWBPaper00035610
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentqRT-PCRPaper_evidenceWBPaper00035610
Curator_confirmedWBPerson2021
WBPhenotype:0000845Paper_evidenceWBPaper00034730
Curator_confirmedWBPerson2021
RemarkMutants had normal sensitivity to cholinergic agonistsPaper_evidenceWBPaper00034730
Curator_confirmedWBPerson2021
Affected_byMoleculeWBMol:00004019Paper_evidenceWBPaper00034730
Curator_confirmedWBPerson2021
WBPhenotype:0001068Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
Phenotype_assayTreatment5 mg/ml serotoninPaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0001183Paper_evidenceWBPaper00053184
Curator_confirmedWBPerson12433
WBPhenotype:0001184Paper_evidenceWBPaper00053184
Curator_confirmedWBPerson12433
WBPhenotype:0001340Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
Phenotype_assayTreatment0.75 mg/ml imipraminePaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0001573Paper_evidenceWBPaper00034730
Curator_confirmedWBPerson2021
RemarkMutants had normal sensitivity to cholinergic agonistsPaper_evidenceWBPaper00034730
Curator_confirmedWBPerson2021
WBPhenotype:0001652Paper_evidenceWBPaper00032446
Curator_confirmedWBPerson2021
WBPhenotype:0001999Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
RemarkThe integration of signals for attraction to diacetyl (100x dilute) and avoidance from copper (100 millimolar) was normal (like wild type) in daf-7(e1372) mutants, resulting in the same number of animals crossing the copper barrier to get to the diacetyl spot compared to wild type controls (Figure 5)Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002819Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBMol:00002862Paper_evidenceWBPaper00037970
Curator_confirmedWBPerson2987
WBPhenotype:0002535Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
RemarkFITC uptake is normal.Paper_evidenceWBPaper00000932
Curator_confirmedWBPerson712
Reference (65)
MethodSubstitution_allele