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WormBase Tree Display for Variation: WBVar00248908

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Name Class

WBVar00248908EvidencePaper_evidenceWBPaper00001756
Name (3)
Sequence_detailsSMapS_parentSequenceY73B6A
Flanking_sequencesacaattcttatctaaaacatttaattttcactagtgaaagaactctttgggatcgcatca
Mapping_targetY73B6A
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00001756
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00027280
WBStrain00030711
WBStrain00030713
WBStrain00030718
WBStrain00030812
LaboratoryPS
StatusLive
AffectsGeneWBGene00003030
TranscriptY73B6A.5c.1VEP_consequencesplice_acceptor_variant
VEP_impactHIGH
HGVScY73B6A.5c.1:c.640-1G>A
Intron_number5/13
Y73B6A.5e.1VEP_consequencesplice_acceptor_variant
VEP_impactHIGH
HGVScY73B6A.5e.1:c.589-1G>A
Intron_number5/13
Y73B6A.5f.1VEP_consequencesplice_acceptor_variant
VEP_impactHIGH
HGVScY73B6A.5f.1:c.553-1G>A
Intron_number3/10
Y73B6A.5b.1VEP_consequencesplice_acceptor_variant
VEP_impactHIGH
HGVScY73B6A.5b.1:c.811-1G>A
Intron_number5/13
Y73B6A.5a.1VEP_consequencesplice_acceptor_variant
VEP_impactHIGH
HGVScY73B6A.5a.1:c.685-1G>A
Intron_number4/12
Y73B6A.5d.1VEP_consequencesplice_acceptor_variant
VEP_impactHIGH
HGVScY73B6A.5d.1:c.760-1G>A
Intron_number6/14
InteractorWBInteraction000519051
WBInteraction000535559
WBInteraction000563586
WBInteraction000563587
WBInteraction000563588
GeneticsInterpolated_map_positionIV3.22834
Mapping_dataIn_multi_point1641
1642
1929
3152
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00001724
Curator_confirmedWBPerson237
WBPhenotype:0000054Paper_evidenceWBPaper00001724
Curator_confirmedWBPerson237
WBPhenotype:0000411Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarksubviable, >90% die as rod-like L1, escapers mostly Egl, Vul; suppresses lin-15Muv; impenetrant P12 to P11 transformation; partial maternal rescue of larval lethality. Effects on male development resemble F and U ablationPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000024PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000640Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkEscapers mostly Egl, Vul; suppresses lin-15Muv; impenetrant P12 to P11 transformation; partial maternal rescue of larval lethality. Effects on male development resemble F and U ablationPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000024PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000651Paper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
RemarkAnimals become severely constipated compared to wild-type worms when grown on lawns of M. nematophilum, whereas they are not constipated when grown on standard E. coli food source, OP50.Paper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were grown on NGM plates seeded with trace (usually 0.01% (v/v)) M. nematophilum in OP50. Strains were cultured on these plates at 25*C.Paper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
WBPhenotype:0000698Paper_evidenceWBPaper00001724
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPerson237
RemarkEscapers mostly Vul;; impenetrant P12 to P11 transformation; partial maternal rescue of larval lethality. Effects on male development resemble F and U ablationPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000024PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001013Paper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
RemarkThe severety of constipation induced in animals grown in the presence of M. nematophilum suggests these animals are hypersensitive to infection by this pathogen.Paper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
PenetranceIncompletePaper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were grown on NGM plates seeded with trace (usually 0.01% (v/v)) M. nematophilum in OP50. Strains were cultured on these plates at 25*C.Paper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
WBPhenotype:0001060Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00001063Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBMol:00005086Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBMol:00002087Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBMol:00004538Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005672PATO:0000460Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBPhenotype:0001061Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00002819Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBMol:00004538Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005670PATO:0000460Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBPhenotype:0001413Paper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
RemarkAnimals failed to swell when exposed to Microbacterium nematophilum, although bacteria were present in the rectum of these animals. Bacteria were visualized by nucleic acid dye SYTO 13.Paper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were grown on NGM plates seeded with trace (usually 0.01% (v/v)) M. nematophilum in OP50. Strains were cultured on these plates at 25*C.Paper_evidenceWBPaper00024311
Curator_confirmedWBPerson712
WBPhenotype:0001645Paper_evidenceWBPaper00005245
WBPaper00006119
WBPaper00029116
Curator_confirmedWBPerson1754
RemarkMutation blocks muscle protein degradation increase in let-60(ga89) animalsPaper_evidenceWBPaper00005245
Curator_confirmedWBPerson1754
Blocks muscle protein degradation induced by clr-1(e1745)Paper_evidenceWBPaper00006119
Curator_confirmedWBPerson1754
Blocks protein degradation in response to treatment with the AGE-1 inhibitor LY-294002Paper_evidenceWBPaper00029116
Curator_confirmedWBPerson1754
Affected_byMoleculeWBMol:00005384Paper_evidenceWBPaper00029116
Curator_confirmedWBPerson1754
Phenotype_assayGenotypelet-60(ga89)Paper_evidenceWBPaper00005245
Curator_confirmedWBPerson1754
clr-1(e1745)Paper_evidenceWBPaper00006119
Curator_confirmedWBPerson1754
Phenotype_not_observedWBPhenotype:0001084Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003571Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005670PATO:0000460Paper_evidenceWBPaper00003955
Curator_confirmedWBPerson712
WBPhenotype:0001660Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
RemarkNo disruption of ASE asymmetry (as seen with lim-6 reporters)Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
Variation_effectHypomorph_reduction_of_functionPaper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
Phenotype_assayGenotypeotIs114, otIs6Paper_evidenceWBPaper00006052
Curator_confirmedWBPerson2021
WBPhenotype:0002193Paper_evidenceWBPaper00044058
Curator_confirmedWBPerson2987
Remark"No allele of egl-17, egl-15 or any other downstream FGF component other than sem-5 had any effect on orientation as single mutants (Table 1), which is probably due to the involvement of sem-5 in one of the other pathways controlling vulval orientation as well as its role in the FGF pathway."Paper_evidenceWBPaper00044058
Curator_confirmedWBPerson2987
EQ_annotationsAnatomy_termWBbt:0006895PATO:0000460Paper_evidenceWBPaper00044058
Curator_confirmedWBPerson2987
WBPhenotype:0002378Paper_evidenceWBPaper00054670
Curator_confirmedWBPerson2706
Remarkanimals avoid OP50 lawns contaminated with Microbacterium nematophilum as wild typePaper_evidenceWBPaper00054670
Curator_confirmedWBPerson2706
Reference (20)
MethodSubstitution_allele