WormBase Tree Display for Variation: WBVar00144047

WBVar00144047 Name: Public_name: e1500
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain (26)
    Laboratory: CB
    Status: Live
  Linked_to: WBVar00144048
    WBVar00144049
    WBVar00144050
    WBVar00144051
    WBVar00296769
  Affects: Gene: WBGene00006822
    Interactor: WBInteraction000518401
      WBInteraction000519095
      WBInteraction000519141
      WBInteraction000521289
  Genetics: Mapping_data (3)
  Description: Phenotype: WBPhenotype:0000001 Paper_evidence: WBPaper00000486
        Curator_confirmed: WBPerson712
        Remark: abnormal body postures; weakly semi-dominant Paper_evidence: WBPaper00000486
            Curator_confirmed: WBPerson712
        Semi_dominant: Paper_evidence: WBPaper00000486
          Curator_confirmed: WBPerson712
      WBPhenotype:0000006 Paper_evidence: WBPaper00000486
          WBPaper00002305
        Curator_confirmed: WBPerson712
          WBPerson557
        Remark: absolute egg-laying deficiency; weakly semi-dominant Paper_evidence: WBPaper00000486
            Curator_confirmed: WBPerson712
        Semi_dominant: Paper_evidence: WBPaper00000486
            WBPaper00002305
          Curator_confirmed: WBPerson712
            WBPerson557
      WBPhenotype:0000022 Paper_evidence: WBPaper00000486
          WBPaper00002305
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
          WBPerson557
        Remark: slightly long Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
          slightly long body; weakly semi-dominant Paper_evidence: WBPaper00000486
            Curator_confirmed: WBPerson712
        Semi_dominant: Paper_evidence: WBPaper00000486
          Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000153 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
      WBPhenotype:0000205 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
        Semi_dominant: Paper_evidence: WBPaper00002305
          Curator_confirmed: WBPerson557
      WBPhenotype:0000514 Paper_evidence: WBPaper00002305
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
          WBPerson557
        Remark: contract and relax when prodded Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000603 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: abnormal muscle Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000611 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Muscle activation defective (flaccid, long). Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000640 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000643 Paper_evidence: WBPaper00032907
          WBPaper00000486
          WBPaper00002305
        Curator_confirmed: WBPerson712
          WBPerson557
        Remark: weakly semi-dominant Paper_evidence: WBPaper00000486
            Curator_confirmed: WBPerson712
        Semi_dominant: Paper_evidence: WBPaper00032907
            WBPaper00000486
          Curator_confirmed: WBPerson712
        Variation_effect: Gain_of_function_undetermined_type: Paper_evidence: WBPaper00032907
            Curator_confirmed: WBPerson712
      WBPhenotype:0000644 Paper_evidence: WBPaper00002305
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
          WBPerson557
        Remark: adults paralysed Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
          Flaccid paralysis. Paper_evidence: WBPaper00002305
            Curator_confirmed: WBPerson557
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Ease_of_scoring: ES3_Easy_to_score: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0000648 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Poor mating in e1500/+ males. Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
        Variation_effect: Neomorph_gain_of_function: Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001068 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Animals placed in serotonin (10 mg/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001101 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
        Remark: Animals resistant to egg laying caused by addition of clomipramine. Paper_evidence: WBPaper00002305
            Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Animals placed in clomipramine (0.75 mg/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001339 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Animals placed in levamisole (100 ug/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001340 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Animals placed in imipramine (0.75 mg/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001807 Paper_evidence: WBPaper00035439
        Curator_confirmed: WBPerson2021
        Remark: A weak alternatively spliced unc-93 exon 9 was only detected in unc-93(e1500) animals. Quantification using Taqman RT-PCR indicated that the alternatively spliced exon 9 was about 1.3% of all spliced unc-93 exon 9 in unc-93(e1500) animals Paper_evidence: WBPaper00035439
            Curator_confirmed: WBPerson2021
        Phenotype_assay: Treatment: RT-PCR Paper_evidence: WBPaper00035439
              Curator_confirmed: WBPerson2021
      WBPhenotype:0001930 Paper_evidence: WBPaper00032907
        Curator_confirmed: WBPerson712
        Remark: Animals were isolated based on altered or fewer muscle arms, observed by an altered pattern of trIs25 reporter expression, which expresses membrane-anchored YFP in select muscles of only the distal row of body wall muscles. Paper_evidence: WBPaper00032907
            Curator_confirmed: WBPerson712
        Recessive: Paper_evidence: WBPaper00032907
          Curator_confirmed: WBPerson712
        Variation_effect: Gain_of_function_undetermined_type: Paper_evidence: WBPaper00032907
            Curator_confirmed: WBPerson712
      WBPhenotype:0004026 Paper_evidence: WBPaper00000486
        Curator_confirmed: WBPerson712
        Remark: animal exhibits an unusual response to touch: when stroked on the head, the animal quickly recoils and relaxes; weakly semi-dominant Paper_evidence: WBPaper00000486
            Curator_confirmed: WBPerson712
        Semi_dominant: Paper_evidence: WBPaper00000486
          Curator_confirmed: WBPerson712
    Phenotype_not_observed: WBPhenotype:0000228 Paper_evidence: WBPaper00000486
        Curator_confirmed: WBPerson712
        Remark: A general elevation of mutation rate due to e1500 is probably not responsible for spontaneous reversion because we have not seen other mutations appear in strains containing e1500. Paper_evidence: WBPaper00000486
            Curator_confirmed: WBPerson712
      WBPhenotype:0000553 Paper_evidence: WBPaper00000486
        Curator_confirmed: WBPerson712
        Remark: Although mild disorganization of the body-wall musculature is evident with polarized light microscopy (Waterston, Fishpool and Brenner 1977), there is an apparently normal level of birefringence. Paper_evidence: WBPaper00000486
            Curator_confirmed: WBPerson712
      WBPhenotype:0001645 Paper_evidence: WBPaper00040284
        Curator_confirmed: WBPerson2987
        Remark: Table S2 Paper_evidence: WBPaper00040284
            Curator_confirmed: WBPerson2987
  Reference (32)
  Method: Allele