WormBase Tree Display for Variation: WBVar00089697

WBVar00089697 Name: Public_name: n715
    Other_name: M01D7.7a.1:c.986-1G>A
      M01D7.7c.1:c.257-1G>A
      M01D7.7b.1:c.830-1G>A
    HGVSg: CHROMOSOME_I:g.1840805G>A
  Sequence_details: SMap: S_parent: Sequence: M01D7
    Flanking_sequences: aattttcaaataaaagggacctctatttca atacggaaaacattcggttcgtgttcgccg
    Mapping_target: M01D7
    Type_of_mutation: Substitution: g a Paper_evidence: WBPaper00002466
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026858
      WBStrain00026986
    Laboratory: MT
    Status: Live
  Linked_to: WBVar00089698
  Affects: Gene: WBGene00001196
    Transcript: M01D7.7b.1 VEP_consequence: splice_acceptor_variant
        VEP_impact: HIGH
        HGVSc: M01D7.7b.1:c.830-1G>A
        Intron_number: 7/8
      M01D7.7a.1 VEP_consequence: splice_acceptor_variant
        VEP_impact: HIGH
        HGVSc: M01D7.7a.1:c.986-1G>A
        Intron_number: 8/9
      M01D7.7c.1 VEP_consequence: splice_acceptor_variant
        VEP_impact: HIGH
        HGVSc: M01D7.7c.1:c.257-1G>A
        Intron_number: 2/3
  Genetics: Interpolated_map_position: I -12.5445
    Mapping_data: In_multi_point: 350
        1293
        1294
      In_pos_neg_data: 3980
  Description: Phenotype: WBPhenotype:0000006 Paper_evidence: WBPaper00000635
          WBPaper00002305
        Curator_confirmed: WBPerson48
          WBPerson557
        Semi_dominant: Paper_evidence: WBPaper00000635
            WBPaper00002305
          Curator_confirmed: WBPerson48
            WBPerson557
      WBPhenotype:0000022 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
      WBPhenotype:0000153 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
      WBPhenotype:0000164 Paper_evidence: WBPaper00000914
        Curator_confirmed: WBPerson48
        Phenotype_assay: Genotype: n715/n715 Paper_evidence: WBPaper00000914
              Curator_confirmed: WBPerson48
      WBPhenotype:0000205 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
        Semi_dominant: Paper_evidence: WBPaper00002305
          Curator_confirmed: WBPerson557
      WBPhenotype:0000545 Paper_evidence: WBPaper00000914
        Curator_confirmed: WBPerson48
        Remark: n715 homozygotes lay no eggs, whereas heterozygotes retain eggs but eventually release most of them. Paper_evidence: WBPaper00000914
            Curator_confirmed: WBPerson48
        Semi_dominant: Paper_evidence: WBPaper00000914
          Curator_confirmed: WBPerson48
      WBPhenotype:0000643 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
      WBPhenotype:0000644 Paper_evidence: WBPaper00000914
          WBPaper00000635
          WBPaper00002305
        Person_evidence: WBPerson261
        Curator_confirmed: WBPerson48
          WBPerson712
          WBPerson557
        Remark: Heterozygotes move slowly. Paper_evidence: WBPaper00000914
            Curator_confirmed: WBPerson48
          uncoordinated paralysed phenotype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
          Flaccid paralysis. Paper_evidence: WBPaper00002305
            Curator_confirmed: WBPerson557
        Semi_dominant: Paper_evidence: WBPaper00000914
          Person_evidence: WBPerson261
          Curator_confirmed: WBPerson48
            WBPerson712
        Phenotype_assay: Genotype: n715/n715 Paper_evidence: WBPaper00000914
              Curator_confirmed: WBPerson48
      WBPhenotype:0000862 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: n715/+ has Type C bloating Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
        Semi_dominant: Person_evidence: WBPerson261
          Curator_confirmed: WBPerson712
      WBPhenotype:0001068 Paper_evidence: WBPaper00000635
          WBPaper00002305
        Curator_confirmed: WBPerson48
          WBPerson557
        Phenotype_assay: Treatment: 5 mg/ml serotonin Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
            Animals placed in serotonin (10 mg/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001101 Paper_evidence: WBPaper00002305
        Curator_confirmed: WBPerson557
        Remark: Animals resistant to egg laying caused by addition of clomipramine. Paper_evidence: WBPaper00002305
            Curator_confirmed: WBPerson557
        Phenotype_assay: Treatment: Animals placed in clomipramine (0.75 mg/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001339 Paper_evidence: WBPaper00000635
          WBPaper00002305
        Curator_confirmed: WBPerson48
          WBPerson557
        Remark: data not shown Paper_evidence: WBPaper00000635
            Curator_confirmed: WBPerson48
        Affected_by: Molecule: WBMol:00004019 Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
        Phenotype_assay: Treatment: 0.1 mg/ml levamisole Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
            Animals placed in levamisole (100 ug/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001340 Paper_evidence: WBPaper00000635
          WBPaper00002305
        Curator_confirmed: WBPerson48
          WBPerson557
        Phenotype_assay: Treatment: 0.75 mg/ml imipramine Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
            Animals placed in imipramine (0.75 mg/ml). Paper_evidence: WBPaper00002305
              Curator_confirmed: WBPerson557
      WBPhenotype:0001341 Paper_evidence: WBPaper00000635
        Curator_confirmed: WBPerson48
        Remark: data not shown Paper_evidence: WBPaper00000635
            Curator_confirmed: WBPerson48
        Phenotype_assay: Treatment: 10 mg/ml phentolamine Paper_evidence: WBPaper00000635
              Curator_confirmed: WBPerson48
  Reference: WBPaper00000635
    WBPaper00014715
    WBPaper00002466
    WBPaper00000914
    WBPaper00044253
    WBPaper00002305
  Method: Substitution_allele