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WormBase Tree Display for Variation: WBVar00089534

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Name Class

WBVar00089534NamePublic_namen487
Other_namen1084Paper_evidenceWBPaper00003631
n1796Paper_evidenceWBPaper00003631
Sequence_detailsSMapS_parentSequenceVF23B12L
Flanking_sequencesTATTGGGTATTGTTTACTCCTAACCGGGTGTCCATAAAATTCTATTGTCCCAGATTTAGG
Mapping_targetVF23B12L
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00003631
Person_evidenceWBPerson117
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
Strain (3)
LaboratoryMT
StatusLive
AffectsGeneWBGene00001170
InteractorWBInteraction000518991
GeneticsInterpolated_map_positionV6.30574
Mapping_dataIn_2_point721
In_multi_point605
606
615
748
942
1179
1180
DescriptionPhenotypeWBPhenotype:0000006Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
RemarkThe penetrance of the egg-laying defect in n487 heterozygotes is heat- sensitive. See Table 7Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
PenetranceHighAs shown in Table 5, 87 percent of heterozygotes are Egl. Under homozygous conditions, 99 percent of hermaphrodites are EglPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
DominantPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_assayTemperature20Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
WBPhenotype:0000022Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000154Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
RemarkMutants show a 34 percent drop in brood size (compared to wild-type)Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
DominantPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_assayTemperature20Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
WBPhenotype:0000207Paper_evidenceWBPaper00056479
Curator_confirmedWBPerson712
RemarkSurprisingly, animals bearing two independent egl-1(dm) mutants that cause the HSNs to undergo premature cell death showed a decrease in DMP frequency (Figure 1B).Paper_evidenceWBPaper00056479
Curator_confirmedWBPerson712
WBPhenotype:0000339Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkTransient bloating Egl. n487/+ is ts Egl (penetrance 85% at 25C, 60% at 20C). Difficult to score (ES2) in adult.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Semi_dominantPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES2_Difficult_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000386Paper_evidenceWBPaper00033433
Curator_confirmedWBPerson2987
RemarkCopper-induced germ cell apoptosis was slightly reduced in egl-1(n487) mutants (Figure 2B).Paper_evidenceWBPaper00033433
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00002862Paper_evidenceWBPaper00033433
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentWorms were exposed to 10 micromolar of copper for 12 hoursPaper_evidenceWBPaper00033433
Curator_confirmedWBPerson2987
WBPhenotype:0000542Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0000545Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
DominantPaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0001005Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0001101Paper_evidenceWBPaper00038382
Curator_confirmedWBPerson712
RemarkThe increase in egg laying with clozapine was not seen in these mutants.Paper_evidenceWBPaper00038382
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003634Paper_evidenceWBPaper00038382
Curator_confirmedWBPerson712
WBPhenotype:0001172Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkHSN cells undergo programmed cell death.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Semi_dominantPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001220Paper_evidenceWBPaper00001133
WBPaper00001105
Curator_confirmedWBPerson2021
RemarkHSNs (which normally undergo apoptosis only in males) die in the mutant hermaphrodites. Authors comment it seems likely that egl-1 mutations cause the cell-specific sexual transformation of hermaphrodite HSNs.Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
HSNs undergo embryonic apoptosis in hermaphroditesPaper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
DominantPaper_evidenceWBPaper00001133
WBPaper00001105
Curator_confirmedWBPerson2021
EQ_annotationsAnatomy_termWBbt:0006830PATO:0000460Paper_evidenceWBPaper00001133
WBPaper00001105
Curator_confirmedWBPerson2021
Temperature_sensitiveHeat_sensitivePaper_evidenceWBPaper00001105
Curator_confirmedWBPerson2021
WBPhenotype:0001333Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
RemarkHSN cell bodies absent.Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0001339Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
Remarkdata not shownPaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
Affected_byMoleculeWBMol:00004019Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
Phenotype_assayTreatment0.1 mg/ml levamisolePaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0001340 (11)
WBPhenotype:0001341Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
Remarkdata not shownPaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
Phenotype_assayTreatment10 mg/ml phentolaminePaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0001617Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
RemarkMutant animals treated with ethosuximide lay eggs at similar stages of development (n=41) as untreated mutants (n=37); unlike that observed with WT animals treated with ethosuximide.Paper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
Phenotype_assayTreatment2mg/ml ethosuximidePaper_evidenceWBPaper00024698
Curator_confirmedWBPerson712
WBPhenotype:0002284Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002288Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002293Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002296Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002299Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002301Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002308Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002312Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002321Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002324Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002335Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0002347Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0004022Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
WBPhenotype:0004023Paper_evidenceWBPaper00043908
Curator_confirmedWBPerson2987
Phenotype_not_observedWBPhenotype:0000386Paper_evidenceWBPaper00035318
Curator_confirmedWBPerson2987
RemarkCobalt-induced germline cell apoptosis was unaffected in egl-1(n487) mutants (Figure 2)Paper_evidenceWBPaper00035318
Curator_confirmedWBPerson2987
Affected_byMoleculeWBMol:00003058Paper_evidenceWBPaper00035318
Curator_confirmedWBPerson2987
Phenotype_assayTreatmentSynchronized young adult hermaphrodites were treated in K-medium with 0.01 millimolar Cobalt chloride for 12 hours, and apoptotic cells were scored after AO staining.Paper_evidenceWBPaper00035318
Curator_confirmedWBPerson2987
WBPhenotype:0001024Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkNo phenotype in male.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Semi_dominantPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001068Paper_evidenceWBPaper00000635
WBPaper00001133
Curator_confirmedWBPerson48
WBPerson2021
DominantPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Phenotype_assayTreatment5 mg/ml serotoninPaper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
7.5 mg/ml serotoninPaper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
Temperature24Paper_evidenceWBPaper00001133
Curator_confirmedWBPerson2021
WBPhenotype:0001336Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
Phenotype_assayTreatmentAs described in Hodgkin, Horvitz, and Brenner (1979), six L4 males and six L4 dpy-11 hermaphrodites incubated for 24 hours, males removed, and hermaphrodites transferred to fresh dishes each day. Cross-progeny are counted.Paper_evidenceWBPaper00000635
Curator_confirmedWBPerson48
WBPhenotype:0001629Paper_evidenceWBPaper00031977
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkAnimals were insensitive to the egg-laying inducing effects of 5HT (serotonin) (n=50).Paper_evidenceWBPaper00031977
Curator_confirmedWBPerson712
Stimulated by serotonin.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Semi_dominantPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
DominantPaper_evidenceWBPaper00031977
Curator_confirmedWBPerson712
Variation_effectHypermorph_gain_of_functionPaper_evidenceWBPaper00031977
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitivePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Reference (17)
MethodSubstitution_allele