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WormBase Tree Display for Variation: WBVar00088536

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Name Class

WBVar00088536EvidencePaper_evidenceWBPaper00004181
NamePublic_namem20
Other_name (15)
HGVSgCHROMOSOME_X:g.10661711G>A
Sequence_detailsSMapS_parentSequenceF11A1
Flanking_sequencesatgcttcacagttggtatgaaaaaagagtgattttaaacgaagaacaactgcggcggagg
Mapping_targetF11A1
Type_of_mutationSubstitutiongaPaper_evidenceWBPaper00004181
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00006154
WBStrain00006224
WBStrain00006356
LaboratoryDR
StatusLive
AffectsGeneWBGene00000908
TranscriptF11A1.3b.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScF11A1.3b.1:c.384G>A
HGVSpCE27585:p.Trp128Ter
cDNA_position384
CDS_position384
Protein_position128
Exon_number4/15
Codon_changetgG/tgA
Amino_acid_changeW/*
F11A1.3e.2VEP_consequencestop_gained
VEP_impactHIGH
HGVScF11A1.3e.2:c.384G>A
HGVSpCE54230:p.Trp128Ter
cDNA_position812
CDS_position384
Protein_position128
Exon_number6/19
Codon_changetgG/tgA
Amino_acid_changeW/*
F11A1.3e.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScF11A1.3e.1:c.384G>A
HGVSpCE54230:p.Trp128Ter
cDNA_position592
CDS_position384
Protein_position128
Exon_number7/20
Codon_changetgG/tgA
Amino_acid_changeW/*
F11A1.3e.4VEP_consequencestop_gained
VEP_impactHIGH
HGVScF11A1.3e.4:c.384G>A
HGVSpCE54230:p.Trp128Ter
cDNA_position545
CDS_position384
Protein_position128
Exon_number6/19
Codon_changetgG/tgA
Amino_acid_changeW/*
F11A1.3f.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScF11A1.3f.1:c.459G>A
HGVSpCE54221:p.Trp153Ter
cDNA_position600
CDS_position459
Protein_position153
Exon_number6/18
Codon_changetgG/tgA
Amino_acid_changeW/*
F11A1.3a.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScF11A1.3a.1:c.561G>A
HGVSpCE27584:p.Trp187Ter
cDNA_position561
CDS_position561
Protein_position187
Exon_number6/18
Codon_changetgG/tgA
Amino_acid_changeW/*
F11A1.3g.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScF11A1.3g.1:c.561G>A
HGVSpCE54229:p.Trp187Ter
cDNA_position592
CDS_position561
Protein_position187
Exon_number7/19
Codon_changetgG/tgA
Amino_acid_changeW/*
F11A1.3e.3VEP_consequencestop_gained
VEP_impactHIGH
HGVScF11A1.3e.3:c.384G>A
HGVSpCE54230:p.Trp128Ter
cDNA_position770
CDS_position384
Protein_position128
Exon_number8/21
Codon_changetgG/tgA
Amino_acid_changeW/*
F11A1.3d.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScF11A1.3d.1:c.459G>A
HGVSpCE39240:p.Trp153Ter
cDNA_position459
CDS_position459
Protein_position153
Exon_number5/16
Codon_changetgG/tgA
Amino_acid_changeW/*
InteractorWBInteraction000051260
WBInteraction000051261
WBInteraction000051262
WBInteraction000051263
WBInteraction000051264
WBInteraction000051265
WBInteraction000051266
WBInteraction000051267
WBInteraction000051268
WBInteraction000051269
WBInteraction000051270
WBInteraction000051271
WBInteraction000051272
WBInteraction000051273
WBInteraction000051274
WBInteraction000051275
WBInteraction000051276
WBInteraction000051277
WBInteraction000051278
WBInteraction000051279
WBInteraction000051280
WBInteraction000051281
WBInteraction000051282
WBInteraction000051283
WBInteraction000051284
WBInteraction000051285
WBInteraction000051286
WBInteraction000051287
WBInteraction000051288
WBInteraction000051289
WBInteraction000051290
WBInteraction000051291
WBInteraction000051292
WBInteraction000051293
WBInteraction000051294
WBInteraction000051295
WBInteraction000051296
WBInteraction000051297
WBInteraction000051298
WBInteraction000051299
WBInteraction000051300
WBInteraction000051301
WBInteraction000051302
WBInteraction000051303
WBInteraction000051304
WBInteraction000051305
WBInteraction000052262
WBInteraction000501543
WBInteraction000517227
WBInteraction000517423
WBInteraction000518676
WBInteraction000518679
WBInteraction000518687
WBInteraction000518692
WBInteraction000518694
WBInteraction000518701
WBInteraction000518712
WBInteraction000518722
WBInteraction000521985
GeneticsInterpolated_map_positionX2.36893
Mapping_dataIn_2_point432
In_multi_point (5)
DescriptionPhenotypeWBPhenotype:0000013Paper_evidenceWBPaper00000504
WBPaper00002149
Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkdefective dauer formationPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
Ease_of_scoringES1_Very_hard_to_scorePerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000093Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarklineage defectsPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0000384Paper_evidenceWBPaper00032266
Curator_confirmedWBPerson712
RemarkIn 37% of daf-12(m20) mutants ray neuron axons showed guidance defects while following commissures to the pre-anal ganglion (data not shown).Paper_evidenceWBPaper00032266
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0006971PATO:0000460Paper_evidenceWBPaper00032266
Curator_confirmedWBPerson712
Life_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00032266
Curator_confirmedWBPerson712
WBPhenotype:0000594Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Remarkcell migration defectsPerson_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001085Paper_evidenceWBPaper00004310
Curator_confirmedWBPerson2021
RemarkAnimals exhibit severely reduced responses to butanonePaper_evidenceWBPaper00004310
Curator_confirmedWBPerson2021
Affected_byMoleculeWBMol:00005086Paper_evidenceWBPaper00004310
Curator_confirmedWBPerson2021
WBPhenotype:0001171Paper_evidenceWBPaper00002149
WBPaper00050052
Curator_confirmedWBPerson712
WBPerson5092
RemarkMean life span slightly shorter than N2 under same conditions. In control experiments, the life spans were nearly like that of wild type at 15.Paper_evidenceWBPaper00002149
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00002149
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Paper_evidenceWBPaper00002149
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were raised at 15C and placed at 25.5C as L4 larvae or young adults for the life span assay.Paper_evidenceWBPaper00002149
Curator_confirmedWBPerson712
Temperature25.5CPaper_evidenceWBPaper00002149
Curator_confirmedWBPerson712
WBPhenotype:0001414Person_evidenceWBPerson261
Curator_confirmedWBPerson712
RemarkMating always successful (ME3) at the permissive temperature, mating never successful (ME0) at 25C.Person_evidenceWBPerson261
Curator_confirmedWBPerson712
Temperature_sensitiveHeat_sensitive25Person_evidenceWBPerson261
Curator_confirmedWBPerson712
WBPhenotype:0001983Paper_evidenceWBPaper00032266
Curator_confirmedWBPerson712
RemarkA high rate of leaving was obtained when the entire DIN-1 binding domain was deleted but the DBD remained intact. Hermaphrodites remained on food like wild-type hermaphrodites. | Unlike wild-type males, the leaving rate of daf-12(m20) males was not decreased by ablation of the gonad.Paper_evidenceWBPaper00032266
Curator_confirmedWBPerson712
EQ_annotationsLife_stageWBls:0000056PATO:0000460Paper_evidenceWBPaper00032266
Curator_confirmedWBPerson712
Phenotype_not_observed (11)
Reference (19)
MethodSubstitution_allele