WormBase Tree Display for Transgene: WBTransgene00033572
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WBTransgene00033572 | Public_name | hhIs254 | |||||
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Summary | [Punc-54::unc-45(I422P)::FLAG; unc-119(+)] | ||||||
Construction | Construct | WBCnstr00042880 | |||||
Construction_summary | human pathogenic variant CeUNC-45(I422P) corresponding to HsUNC-45B(S403P) | ||||||
Genetic_information | Integrated | ||||||
Phenotype | WBPhenotype:0000119 | Paper_evidence | WBPaper00065280 | ||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Transgenic expression of the C. elegans ortholog CeUNC-45(I422P) of the human pathogenic variant HsUNC-45B(S403P) reduces wild-type worm motility and stabilizes the muscle-specific UFD model substrate in the wild-type and unc-45(m94) background compared with an UNC-45(WT) transgene. | Paper_evidence | WBPaper00065280 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0000273 | Paper_evidence | WBPaper00065280 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Transgenic expression of the C. elegans ortholog CeUNC-45(I422P) of the human pathogenic variant HsUNC-45B(S403P) reduces wild-type worm motility and stabilizes the muscle-specific UFD model substrate in the wild-type and unc-45(m94) background compared with an UNC-45(WT) transgene. | Paper_evidence | WBPaper00065280 | ||||
Curator_confirmed | WBPerson712 | ||||||
Reference | WBPaper00065280 | ||||||
Species | Caenorhabditis elegans |