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WormBase Tree Display for Transgene: WBTransgene00033572

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Name Class

WBTransgene00033572Public_namehhIs254
Summary[Punc-54::unc-45(I422P)::FLAG; unc-119(+)]
ConstructionConstructWBCnstr00042880
Construction_summaryhuman pathogenic variant CeUNC-45(I422P) corresponding to HsUNC-45B(S403P)
Genetic_informationIntegrated
PhenotypeWBPhenotype:0000119Paper_evidenceWBPaper00065280
Curator_confirmedWBPerson712
RemarkTransgenic expression of the C. elegans ortholog CeUNC-45(I422P) of the human pathogenic variant HsUNC-45B(S403P) reduces wild-type worm motility and stabilizes the muscle-specific UFD model substrate in the wild-type and unc-45(m94) background compared with an UNC-45(WT) transgene.Paper_evidenceWBPaper00065280
Curator_confirmedWBPerson712
WBPhenotype:0000273Paper_evidenceWBPaper00065280
Curator_confirmedWBPerson712
RemarkTransgenic expression of the C. elegans ortholog CeUNC-45(I422P) of the human pathogenic variant HsUNC-45B(S403P) reduces wild-type worm motility and stabilizes the muscle-specific UFD model substrate in the wild-type and unc-45(m94) background compared with an UNC-45(WT) transgene.Paper_evidenceWBPaper00065280
Curator_confirmedWBPerson712
ReferenceWBPaper00065280
SpeciesCaenorhabditis elegans