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WormBase Tree Display for Transgene: WBTransgene00027076

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Name Class

WBTransgene00027076Public_namernySi53
Summary[Tau-T4 (K274Q; K281Q) *rnySi24]
ConstructionConstructWBCnstr00041904
Construction_summaryacetylation mimicking (K to Q) mutations at the K274 and K281 positions of the TauT4 isoform
Genetic_informationIntegrated
MapII
PhenotypeWBPhenotype:0000461Paper_evidenceWBPaper00060195
Curator_confirmedWBPerson712
Remarkinduction of mitophagy occurring in response to the mitochondrial toxin paraquat was entirely suppressed by expression of the T231E and K274/281 mutants, but not of wild type TauT4 itselfPaper_evidenceWBPaper00060195
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0001719Paper_evidenceWBPaper00060195
Curator_confirmedWBPerson712
RemarkUPRmt activation in the K274/281Q acetyl-mimetic mutant, which like T231E caused neurodegeneration and an inability to trigger mitophagy in response to paraquat treatment (Guha et al., 2020), failed to reach significance (p = 0.1), but also had increased scatter in the baseline signal (Fig. 1C).Paper_evidenceWBPaper00060195
Curator_confirmedWBPerson712
ReferenceWBPaper00060195
SpeciesCaenorhabditis elegans