WormBase Tree Display for Transgene: WBTransgene00027076
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WBTransgene00027076 | Public_name | rnySi53 | |||||
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Summary | [Tau-T4 (K274Q; K281Q) *rnySi24] | ||||||
Construction | Construct | WBCnstr00041904 | |||||
Construction_summary | acetylation mimicking (K to Q) mutations at the K274 and K281 positions of the TauT4 isoform | ||||||
Genetic_information | Integrated | ||||||
Map | II | ||||||
Phenotype | WBPhenotype:0000461 | Paper_evidence | WBPaper00060195 | ||||
Curator_confirmed | WBPerson712 | ||||||
Remark | induction of mitophagy occurring in response to the mitochondrial toxin paraquat was entirely suppressed by expression of the T231E and K274/281 mutants, but not of wild type TauT4 itself | Paper_evidence | WBPaper00060195 | ||||
Curator_confirmed | WBPerson712 | ||||||
Phenotype_not_observed | WBPhenotype:0001719 | Paper_evidence | WBPaper00060195 | ||||
Curator_confirmed | WBPerson712 | ||||||
Remark | UPRmt activation in the K274/281Q acetyl-mimetic mutant, which like T231E caused neurodegeneration and an inability to trigger mitophagy in response to paraquat treatment (Guha et al., 2020), failed to reach significance (p = 0.1), but also had increased scatter in the baseline signal (Fig. 1C). | Paper_evidence | WBPaper00060195 | ||||
Curator_confirmed | WBPerson712 | ||||||
Reference | WBPaper00060195 | ||||||
Species | Caenorhabditis elegans |