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WormBase Tree Display for Transgene: WBTransgene00025262

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Name Class

WBTransgene00025262Summary[glr-1p::ceh-17; lin-15(+)]
ConstructionConstructWBCnstr00039998
Construction_summary"we cloned an amplicon encompassing the entire genomic ceh-17 coding sequence"; "To ectopically express ceh-17 in glr-1+ neurons, we cloned the same ceh-17 genomic fragment as above into the NheI-NcoI sites of the PV6 plasmid, containing the glr-1 promoter (a gift from S. Clark) to produce pglr-1::ceh-17 (pNP77)." "These plasmids were coinjected with a plasmid containing the wild-type lin-15 gene (a gift from S. Clark) into the lin-15(n765ts) mutant and transgenic non-multivulva lines were established at 25C."
Genetic_informationPhenotypeWBPhenotype:0000315Person_evidenceWBPerson499
Curator_confirmedWBPerson499
Remarkwhen tap on the tail, worms move backward (NP unpublished)Person_evidenceWBPerson499
Curator_confirmedWBPerson499
Caused_by_geneWBGene00000440Person_evidenceWBPerson499
Curator_confirmedWBPerson499
EQ_annotationsGO_termGO:0007638PATO:0000460Person_evidenceWBPerson499
Curator_confirmedWBPerson499
WBPhenotype:0002490Paper_evidenceWBPaper00004283
Curator_confirmedWBPerson499
RemarkIn 37% of glr-1p::ceh-17 animals (n=54), an unidentified glr-1+ head neuron was seen projecting ectopically beyond the nerve ring towards the head, sometimes as far as the nose. In addition, in 6% of cases, the glr-1+ tail neuron PVQ had acquired a posterior projection never seen in wild type.Paper_evidenceWBPaper00004283
Curator_confirmedWBPerson499
Caused_by_geneWBGene00000440Paper_evidenceWBPaper00004283
Curator_confirmedWBPerson499
EQ_annotationsAnatomy_termWBbt:0006976PATO:0000460Paper_evidenceWBPaper00004283
Curator_confirmedWBPerson499
GO_termGO:0030424PATO:0000628Paper_evidenceWBPaper00004283
Curator_confirmedWBPerson499
ReferenceWBPaper00004283
SpeciesCaenorhabditis elegans