WormBase Tree Display for Transgene: WBTransgene00025262
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WBTransgene00025262 | Summary | [glr-1p::ceh-17; lin-15(+)] | |||||||
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Construction | Construct | WBCnstr00039998 | |||||||
Construction_summary | "we cloned an amplicon encompassing the entire genomic ceh-17 coding sequence"; "To ectopically express ceh-17 in glr-1+ neurons, we cloned the same ceh-17 genomic fragment as above into the NheI-NcoI sites of the PV6 plasmid, containing the glr-1 promoter (a gift from S. Clark) to produce pglr-1::ceh-17 (pNP77)." "These plasmids were coinjected with a plasmid containing the wild-type lin-15 gene (a gift from S. Clark) into the lin-15(n765ts) mutant and transgenic non-multivulva lines were established at 25C." | ||||||||
Genetic_information | Phenotype | WBPhenotype:0000315 | Person_evidence | WBPerson499 | |||||
Curator_confirmed | WBPerson499 | ||||||||
Remark | when tap on the tail, worms move backward (NP unpublished) | Person_evidence | WBPerson499 | ||||||
Curator_confirmed | WBPerson499 | ||||||||
Caused_by_gene | WBGene00000440 | Person_evidence | WBPerson499 | ||||||
Curator_confirmed | WBPerson499 | ||||||||
EQ_annotations | GO_term | GO:0007638 | PATO:0000460 | Person_evidence | WBPerson499 | ||||
Curator_confirmed | WBPerson499 | ||||||||
WBPhenotype:0002490 | Paper_evidence | WBPaper00004283 | |||||||
Curator_confirmed | WBPerson499 | ||||||||
Remark | In 37% of glr-1p::ceh-17 animals (n=54), an unidentified glr-1+ head neuron was seen projecting ectopically beyond the nerve ring towards the head, sometimes as far as the nose. In addition, in 6% of cases, the glr-1+ tail neuron PVQ had acquired a posterior projection never seen in wild type. | Paper_evidence | WBPaper00004283 | ||||||
Curator_confirmed | WBPerson499 | ||||||||
Caused_by_gene | WBGene00000440 | Paper_evidence | WBPaper00004283 | ||||||
Curator_confirmed | WBPerson499 | ||||||||
EQ_annotations | Anatomy_term | WBbt:0006976 | PATO:0000460 | Paper_evidence | WBPaper00004283 | ||||
Curator_confirmed | WBPerson499 | ||||||||
GO_term | GO:0030424 | PATO:0000628 | Paper_evidence | WBPaper00004283 | |||||
Curator_confirmed | WBPerson499 | ||||||||
Reference | WBPaper00004283 | ||||||||
Species | Caenorhabditis elegans |