WormBase Tree Display for Transgene: WBTransgene00005249
expand all nodes | collapse all nodes | view schema
WBTransgene00005249 | Public_name | zxIs6 | ||||||
---|---|---|---|---|---|---|---|---|
Summary | [unc-17p::ChR2(H134R)::YFP + lin-15(+)] | |||||||
Synonym | [Punc-17::chop-2(H134R)-yfp; lin-15(+)] | |||||||
[punc-17::ChR2(H134R)::YFP; lin-15+] | ||||||||
Construction | Construct | WBCnstr00005226 | ||||||
Genetic_information | Integrated | |||||||
Phenotype | WBPhenotype:0000153 | Paper_evidence | WBPaper00032190 | |||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Animals showed rapid and sustained body contraction to 92% of intial body length after illumination (photoactivation of ChR2-YFP in cholinergic neurons). | Paper_evidence | WBPaper00032190 | |||||
Curator_confirmed | WBPerson712 | |||||||
Caused_by_other | Human channelrhodopsin-2 (H134R) | Paper_evidence | WBPaper00032190 | |||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Treatment | ChR2-YFP was activated in animals swimming in liquid, or on solid substrates, by applying 450-490 nm light. The chromophore essential fro ChR2 function was supplied by growing transgenic animals on medium containing all-trans retinal. | Paper_evidence | WBPaper00032190 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0000567 | Paper_evidence | WBPaper00032190 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Dorsal coiling was triggered within ~10 sec of photostimulation of ChR2-YFP in cholinergic neurons. | Paper_evidence | WBPaper00032190 | |||||
Curator_confirmed | WBPerson712 | |||||||
Caused_by_other | Human channelrhodopsin-2 (H134R) | Paper_evidence | WBPaper00032190 | |||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Treatment | ChR2-YFP was activated in animals swimming in liquid, or on solid substrates, by applying 450-490 nm light. The chromophore essential fro ChR2 function was supplied by growing transgenic animals on medium containing all-trans retinal. | Paper_evidence | WBPaper00032190 | ||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_not_observed | WBPhenotype:0001316 | Paper_evidence | WBPaper00032190 | |||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Exogenous neurotransmitter evoked currents were no different from wild-type. | Paper_evidence | WBPaper00032190 | |||||
Curator_confirmed | WBPerson712 | |||||||
Caused_by_other | Human channelrhodopsin-2 (H134R) | Paper_evidence | WBPaper00032190 | |||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Treatment | ChR2-YFP was activated in animals swimming in liquid, or on solid substrates, by applying 450-490 nm light. The chromophore essential fro ChR2 function was supplied by growing transgenic animals on medium containing all-trans retinal. | Paper_evidence | WBPaper00032190 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001318 | Paper_evidence | WBPaper00032190 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | The frequency and amplitude of endogenous miniature postsynaptic currents of photostimulated ChR2-YFP containing cholinergic neurons were comparable to wild-type. | Paper_evidence | WBPaper00032190 | |||||
Curator_confirmed | WBPerson712 | |||||||
Caused_by_other | Human channelrhodopsin-2 (H134R) | Paper_evidence | WBPaper00032190 | |||||
Curator_confirmed | WBPerson712 | |||||||
Phenotype_assay | Treatment | ChR2-YFP was activated in animals swimming in liquid, or on solid substrates, by applying 450-490 nm light. The chromophore essential fro ChR2 function was supplied by growing transgenic animals on medium containing all-trans retinal. | Paper_evidence | WBPaper00032190 | ||||
Curator_confirmed | WBPerson712 | |||||||
Associated_with | Strain | WBStrain00040913 | ||||||
WBStrain00055728 | ||||||||
WBStrain00055731 | ||||||||
Reference (39) | ||||||||
Species | Caenorhabditis elegans |