WormBase Tree Display for RNAi: WBRNAi00110188

WBRNAi00110188 Homol: Homol_homol: C27C12:RNAi
  Sequence_info: DNA_text: ATGGCACTTCACGAGCCACCTTCCAAACTTAATAGGCACTCTCATTCAAATTTATTAAAACCTCCGTCATTAAATAAACCAATACTGACGTTTGCTGACAATGATTGCCTGAAAACGCCAACTATGAATGATATGCTTAAGACACCCACAGTAAATTCACCACGACACACACCGATGAATATTGACGGGACGCCTAAAGTCAATGGATTTTCTGGATTTACTCCTCAAACCGATCAGAAATTCTTTGGCGAGCACGAGCCACTGTTCAACCAAATGCACACAACAACACTAATGCCGGCACCATCATCGTCATACAAGGAGCCAGCTTACAGTAGTGAGCAGCCGTCTAGCTCTTCGGATGAGGCGAAGCCTAAGGAGCTGCTAGGAAGTAATAGTTTTGGAGTACCGCGCATGACGAACGGGAACAGTAAGCAGAAACCAGAAGAGTTGACGTTAAAAGATATTGAGATCAGTTCTACAGGACCGGGTGGTGTAGATTCTCCAGGCTTATCTGCTGCCATGTTCCAGTTTTCGCCAATGGTAGAACACTTTTTGCAAAATCTCACTAATAAAGCAGGCCTGCCAGAATTAGTTGTGGACTCTAAAACAGCGGGATTAAACCATCAAGAACCATCCGATTTGATAAAGTCTGTCCAAGTACGGAGGAGCTCGATAGAGGATCAAAAATTCAGTGATGTTCTGCATGTGCCGACACTGCCACGAAAGACAAGTGAACCATCGCATCTTGGGTCTTCTCTTCAAAACGAGCATCCACAATCCAACTCTCGACCGTCTACCGTAATCCCACGAGTACAGAGGACCAACACGTCAGCGAGCCTCACAAGATCTATGGATCATTCATCAATGTCGCCAATTTCTGCGCATGATGACCCGTATTCCAATTCAGCAAGCTATTCTAGTCTCTCGACTCATACGTCATTTTCAGACAGCGCTAGCTTGGCACATTTCGAGCCAAAAACCGAGCCAATGGATGACTACAGCTACAACTTCTCAGATAATGACTTCAATTCCTTTGAGTTTTCATCCACTTCTGAAGAGCTAAAGAATATTGGCTGCCAAAAAATGAAGTCCTCAAAGATGCCTCTCCAAGACAGACCGTACAAGTGTCCACGAGATGGATGTGACAGGAGGTTCTCGAGAAGTGACGAGCTGACGAGACATATTAGGATTCATACAGGCCAAAAGCCATTCCAGTGCCGAATTTGTATGCGTGCCTTCTCCCGCTCGGACCATTTGACGACCCACGTGCGCACTCACACTGGCGAAAAACCATTCTCCTGTGACATTTGTGGCCGGAAATTCGCGCGAAGTGATGAACGAAAGCGGCACACGAAAGTTCACAAGACATCGCGTTCAGGGTCATAA
  Experiment: Genotype: rrf-1(pk1417)
    Delivered_by: Injection
  Inhibits: Predicted_gene: C27C12.2 Inferred_automatically: RNAi_primary
    Gene: WBGene00007772 Inferred_automatically: RNAi_primary
    Transcript: C27C12.2.1 Inferred_automatically: RNAi_primary
  Species: Caenorhabditis elegans
  Reference: WBPaper00037082
  Phenotype: WBPhenotype:0000186 Remark: Hermaphrodites accumulate degraded oocytes in the proximal gonad and (or) differentiated oocytes in the distal gonad. Authors found that egrh-1(RNAi) was less effective in rrf-1(pk1417) than in a wild-type background. "Indeed rrf-1(pk1417); egrh-1(RNAi) animals exhibited only a slightincrease in the frequency of oocyte defects when compared with untreated rrf-1(pk1417) mutants. Thus, we conclude that egrh-1 functions in the soma." rrf-1(pk1417) mutants are specifically resistant to RNAi in the soma but remain sensitive to RNAi in the germline.
      Penetrance: Low
        Range: 12
    WBPhenotype:0001668 Remark: Hermaphrodites accumulate degraded oocytes in the proximal gonad and (or) differentiated oocytes in the distal gonad. Authors found that egrh-1(RNAi) was less effective in rrf-1(pk1417) than in a wild-type background. "Indeed rrf-1(pk1417); egrh-1(RNAi) animals exhibited only a slightincrease in the frequency of oocyte defects when compared with untreated rrf-1(pk1417) mutants. Thus, we conclude that egrh-1 functions in the soma." rrf-1(pk1417) mutants are specifically resistant to RNAi in the soma but remain sensitive to RNAi in the germline.
      Penetrance: Low
        Range: 12
  Remark: Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.
  Method: RNAi