WormBase Tree Display for Picture: WBPicture0000013288

WBPicture0000013288 Description: Figure 6. PQM-1 Is a Major Regulator of Age-Related Loss of Gene Expression (A) The distribution of genes classified by Budovskaya et al. (2008) as 'age-regulated' versus our ranking shows that our classes I and II are both strongly affected during normal aging. (B) Differential expression of all genes between day 11 and day 2 of adulthood, shown in the context of our ranking. (C) Expression change (mean log ratio) for class I, class II, and other genes as a function of age, day 2 of adulthood being the reference. (D) Fold enrichment versus genome-wide average of ChIP-seq binding sites in the 1% of genes most strongly downregulated with age. (E) Average expression of regulons (sets of targets genes as defined based on ChIP-seq data) for various transcription factors assayed by Niu et al. (2011), shown as a function of advancing age. (F-H) DAF-16 becomes more cytoplasmic with age, and nuclear localization of PQM-1::GFP decreases significantly with age. Data are represented as mean +/- SEM (G and H).
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  Crop: Crop_picture: WBPicture0000013289
  Acknowledgment: Template: Reprinted from <Journal_URL>, <Article_URL>, Copyright <Publication_year>, with permission from <Publisher_URL>.
    Publication_year: 2013
    Article_URL: DOI id 10.1016/j.cell.2013.07.006
    Journal_URL: Cell
    Publisher_URL: Elsevier
  Reference: WBPaper00044005