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| WBPicture0000008604 | Description | Figure 1. LAB-1 protein conservation and phenotypes. (A) Sequence alignment between LAB-1 and its homologs in other Caenorhabditis species (C. elegans: C03D6.6; Caenorhabditis briggsae: CBP06688; Caenorhabditis remanei: CR03512). A cosmid (1003.1) carrying the putative Caenorhabditis brenneri (former PB2801) lab-1 homolog was identified by a BLAST database search of the C.elegans LAB-1 sequence against a C. brenneri cosmid library (Genome Sequencing Center, Washington University School of Medicine). Prediction of the coding sequence in the respective region in 1003.1 and conceptual translation were performed using FGENESH+ (http://www.softberry.com/berry.phtml). Residue conservation is shown in different shades of blue (light, 75% conserved; dark, 100% conserved). The location of the putative first methionine in lab-1(tm1791) is indicated by an asterisk. The [(R/K) (V/I) X (F/W)] core motif associated with binding and regulation of PP1/Glc7 proteins is shown below a solid line. The C terminus peptide region used for antibody production is marked by a double line. (B) Percentage of embryonic lethality and incidence of males observed among the progeny of worms of the indicated genotypes. Error bars represent standard deviation of the mean. (C) Number of DAPI-stained bodies present in 1 oocytes at diakinesis in the indicated genotypes. Bar, 2 μm. (D) Immunolocalization of LAB-1 in meiotic prophase I. No signal is detected on mature sperm (arrow in DAPI panel). Bar, 20 μm. | |||
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| Name | F1.large.jpg | ||||
| Crop | Crop_picture | WBPicture0000008605 | |||
| Acknowledgment | Template | WormBase wishes to thank <Journal_URL> for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Reprinted from <Journal_URL>, <Article_URL>. Copyright (<Publication_year>) with permission from <Publisher_URL>. | |||
| Publication_year | 2008 | ||||
| Article_URL | DOI | id | 10.1101/gad.1691208 | ||
| Journal_URL | Genes&Development | ||||
| Publisher_URL | ColdSpringHarborLabPress | ||||
| Reference | WBPaper00032269 |
