WormBase Tree Display for Interaction: WBInteraction000543599
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| WBInteraction000543599 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00007659 | Interactor_type | Trans_regulated | |
| Transgene | WBTransgene00020081 | ||||
| Construct | WBCnstr00019406 | ||||
| WBGene00003926 | Interactor_type | Trans_regulator | |||
| Interaction_summary | " To disrupt UPS function, we first performed RNAi knock-down of ubiquitin, pas-5 and rpn-2 in C17H1.6p::gfp and F26F2.1p::gfp transgenic animals. Strikingly, RNAi against the UPS components dramatically induced GFP expression in the intestine in both of these strains (Figure 6B). To confirm these results we performed qRT-PCR and saw levels of endogenous C17H1.6 and F26F2.1 mRNA transcripts also increased by UPS RNAi (Figure 6C)." | ||||
| Detection_method | Construct | ||||
| Reporter_gene | [C17H1.6p::gfp] | ||||
| Transgene | |||||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Negative_regulate | Anatomy_term | WBbt:0005772 | ||
| Paper | WBPaper00045401 | ||||
| Remark | Fig. 6b |
