WormBase Tree Display for Interaction: WBInteraction000542616
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WBInteraction000542616 | Interaction_type | Regulatory | Change_of_expression_level | ||
---|---|---|---|---|---|
Interactor | Interactor_overlapping_gene | WBGene00003025 | Interactor_type | Trans_regulator | |
WBGene00006351 | Interactor_type | Trans_regulated | |||
WBGene00002016 | Interactor_type | Trans_regulated | |||
WBGene00002008 | Interactor_type | Trans_regulated | |||
WBGene00002010 | Interactor_type | Trans_regulated | |||
Interaction_summary | "We observe the greatest degree of regulation, however, amongst the 16 regulators of cytoprotective gene expression that regulate 2 or more of the tested cytoprotective pathways. lin-40 gene inactivation disrupts psod-3::gfp induction 17-fold, and pgst-4::gfp 2-fold. let-92 gene inactivation results in the most potent disruption of pgst-4::gfp induction, decreasing expression 25-fold, and inhibiting induction of psod-3::gfp and phsp-6::gfp by 3- and 4-fold, respectively. ima-3 and elt-2 gene inactivations both dramatically decrease induction of phsp-6::gfp by antimycin. ima-3 gene inactivation additionally inhibits the induction of pgst-4::gfp (4-fold). elt-2, like let-70 and cpsf-2, is required for the appropriate regulation of all four tested cytoprotective pathways (Table 1, Figure 1)... Induction of phsp-16.2::gfp following heat shock and the expression of a non-stress-induced fusion gene, psur-5::gfp, were quantified to control for generic transgene silencing phenotypes; none of these gene inactivations were potent transgene silencers (Table S4)" | ||||
Detection_method | Reporter_gene | [hsp-4p::gfp], [hsp-6p::gfp], [hsp-16.2p::gfp], [sur-5p::gfp] | |||
Regulation_level | Transcriptional | ||||
Paper | WBPaper00041330 | ||||
Remark | Table 1, Fig. 1, Table S4; hsp-16.2::gfp induced via 37C treatment for 1hr |