WormBase Tree Display for Interaction: WBInteraction000542430
expand all nodes | collapse all nodes | view schema
| WBInteraction000542430 | Interaction_type | Genetic | Oversuppression | ||
|---|---|---|---|---|---|
| GI_module_two | Super_suppressing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00001709 | Interactor_type | Effector | |
| WBGene00000958 | Interactor_type | Affected | |||
| WBGene00196366 | Interactor_type | Effector | |||
| Variation_interactor | WBVar00145675 | Interactor_type | Effector | ||
| WBVar00248986 | Interactor_type | Affected | |||
| Interaction_summary | "We evaluated this question by crossing the grk-2(gk268) and grk-2(rt97) alleles with strains that are constitutive egg layers. These strains include a gain-of-function strain that has activated Gαq (egl-30(ep271)) as well as loss-of-function strains that are defective in Gαo (goa-1(n1134)), the G protein that inhibits egg laying; EAT-16 (eat-16(ep273)), the regulator of G protein signaling (RGS) protein of Gαq; or diacylglycerol kinase (dgk-1(sy428)), a potential effector enzyme that phosphorylates diacylglycerol. Interestingly, the constitutive egg laying phenotype in these strains could be effectively suppressed by grk-2(lf) (Fig. 3A), suggesting that GRK-2 may function downstream of these proteins in the egg laying pathway." | ||||
| Throughput | Low_throughput | ||||
| Interaction_phenotype | WBPhenotype:0000004 | ||||
| Paper | WBPaper00050796 | ||||
| Remark | Figure 3A |
