WormBase Tree Display for Interaction: WBInteraction000524219
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WBInteraction000524219 | Interaction_type | Regulatory | |||
---|---|---|---|---|---|
Interactor | Interactor_overlapping_gene | WBGene00000936 | Interactor_type | Cis_regulated | |
Feature_interactor | WBsf945413 | Interactor_type | Cis_regulator | ||
Interaction_summary | The M4 enhancer contains two candidate CEH-28 binding sites: one located at bp -825, which is conserved in other Caenorhabditis species, and a second at bp -738. Authors tested the effect of mutations in each of these sites on M4 enhancer activity either alone or in a double mutant. Mutation of the site at -825 led to a decrease in the intensity of GFP expression level and a moderate decrease in the frequency of animals expressing GFP, whereas mutation of the site at -738 had little effect on enhancer activity. In comparison, a double mutant affecting both of these sites had a stronger reduction in both the intensity and frequency of GFP expression in M4, | ||||
Regulation_result | Positive_regulate | Anatomy_term | WBbt:0004467 | ||
Paper | WBPaper00045065 |