WormBase Tree Display for Interaction: WBInteraction000521601
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| WBInteraction000521601 | Interaction_type | Genetic | Suppression | ||
|---|---|---|---|---|---|
| GI_module_two | Suppressing | ||||
| Interactor | Interactor_overlapping_gene | WBGene00006818 | Interactor_type | Effector | |
| WBGene00003167 | Interactor_type | Affected | |||
| Expr_pattern | Expr88 | ||||
| Transgene | WBTransgene00020029 | ||||
| Construct | WBCnstr00019354 | ||||
| Variation_interactor | WBVar00266642 | Interactor_type | Affected | ||
| WBVar00266650 | Interactor_type | Affected | |||
| Interaction_summary | Non-null mec-3 alleles cause a 90-95% penetrant mechanosensory defective phenotype and significantly reduce the expression of MEC-7. mec-3(u298) and mec-3(u312) animals carrying unc-86/VP16 are nearly wild type in response to touch compared to the parent mec-3 mutant strains. This sup- pression is dependent on the VP16 activation domain, because transgenic unc-86(+) does not suppress these mec-3 alleles, and it is dependent on the POU DNA-binding domain, because unc-86/VP16(-POU) does not suppress these mec-3 alleles | ||||
| Detection_method | Construct | ||||
| Transgene | |||||
| Throughput | Low_throughput | ||||
| Interaction_phenotype | WBPhenotype:0001676 | ||||
| Paper | WBPaper00002742 |
