WormBase Tree Display for Interaction: WBInteraction000504537
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| WBInteraction000504537 | Interaction_type | Regulatory | Change_of_localization | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00000083 | Interactor_type | Trans_regulator | |
| WBGene00000608 | Interactor_type | Trans_regulated | |||
| Interaction_summary | COL-19::GFP protein fusion reporter construct is expressed in annuli and lateral alae of the adult cuticle. In adt-2(wk156) mutants, which have the least severe body size phenotype, no significant disruption of the COL-19::GFP organization is observed. In these mutants, the annuli are constricted, which could be either a primary or secondary defect, but is also seen in some collagen mutants. Animals treated with adt-2(RNAi) show significant disruptions of the lateral cuticle overlying the seam cells. Constrictions of the annuli in adt-2(RNAi) worms is also detected. COL-19::GFP localization in adt-2(tm975/wk156) transheterozygous animals reveals patches of disorganized annuli and structural defects in the alae. The defects are discontinuous alae and alae with two or four ridges as compared to three ridges in the wild- type worms. These disruptions may partially explain the reduced body size in adt-2 mutants and knockdowns. | ||||
| Detection_method | Reporter_gene | [col-19::gfp], translational fusion | |||
| Regulation_level | Post_translational | ||||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0005755 | ||
| WBbt:0007832 | |||||
| Paper | WBPaper00038069 |
