WormBase Tree Display for Interaction: WBInteraction000003092
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| WBInteraction000003092 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00003167 | Interactor_type | Trans_regulated | |
| Transgene | WBTransgene00000680 | ||||
| WBGene00006818 | Interactor_type | Trans_regulator | |||
| Transgene | WBTransgene00020023 | ||||
| Interaction_summary | The sister of the PVDR cell will express mec-3-lacZ response to jeEx100 (unc-86+++). At a low frequency (3%), an extra mec-3-expressing cell adjacent to PVDR is seen in a ced(+) ; jeEx100 strain. When this occurs, there are five neuronal nuclei in the PVDR cluster, suggesting a transformation into a mec-3-expressing cell of the PVDR sister, which normally undergoes programmed cell death. When cell death is blocked with a ced-4(n1162) mutation, the frequency of ectopic mec-3-LacZ cells increases to 41%, indicating that in the presence of a high unc-86 gene dose, the PVDR sister can often express mec-3-LacZ if it does not first undergo programmed cell death . | ||||
| Detection_method | Reporter_gene | jeEx100 | |||
| Transgene | |||||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0004088 | ||
| Paper | WBPaper00002480 |
