WormBase Tree Display for Gene_class: pfd
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| pfd | Description | PreFolDin (molecular chaperone) |
|---|---|---|
| Designating_laboratory | MX | |
| Genes (43) | ||
| Old_member | Ppa-pfd-3 | |
| Cjp-pfd-4 | ||
| Cre-pfd-1 | ||
| Cjp-pfd-4.2 | ||
| Remark | Prefoldin (PFD) is a jellyfish-shaped hexameric molecular chaperone complex that is assembled from six related protein subunits. It is conserved in eukaryotes and archaea but lacking in bacteria. In eukaryotes, each protein subunit is encoded by separate genes; the C.elegans genes are termed pfd-1 to pfd-6, the human genes PFDN1-PFDN6, and the yeast genes gim1-gim6 (gim refers to "Genes Involved in Microtubule biogenesis"). The function of eukaryotic prefoldin is to stabilize newly-made, non-native actin and tubulin species and to transfer them to another molecular chaperone, the chaperonin CCT, for folding assistance. Prefoldin may also act as a cofactor of CCT to |
