WormBase Tree Display for Gene: WBGene00050875
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WBGene00050875 | SMap | S_parent | Sequence | ZK1025 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | bah-1 | Paper_evidence | WBPaper00035152 | |||
Person_evidence | WBPerson125 | ||||||
Sequence_name | ZK1025.7 | ||||||
Molecular_name | ZK1025.7 | ||||||
ZK1025.7.1 | |||||||
CE19334 | |||||||
Other_name | CELE_ZK1025.7 | Accession_evidence | NDB | BX284601 | |||
Public_name | bah-1 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | bah | ||||||
Allele (64) | |||||||
Strain | WBStrain00032417 | ||||||
WBStrain00004729 | |||||||
WBStrain00004755 | |||||||
WBStrain00005601 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00104538 | ||||||
00104539 | |||||||
00104540 | |||||||
00104541 | |||||||
Ortholog (45) | |||||||
Paralog (38) | |||||||
Structured_description | Concise_description | bah-1 encodes a protein with a DUF23 domain, a domain found in insects, plants, bacteria and two vertebrates, the frog and the fish, Tetraodon, but absent from mammalian genomes; bah-1 normally functions to contribute to the integrity of the nematode cuticle; bah-1 is also required for the surface characteristics of the elegans cuticle that are required for the binding of bacterial biofilms; bah-1 expression is down-regulated in mutants of the TGF-beta pathway, like daf-7, daf-8 or daf-14, as such, these mutants do not form biofilms, suggesting that the TGF-beta pathway regulates bah-1 and possibly other genes required for biofilm binding; bah-1 is expressed in the seam cells which are part of the cuticle-synthesizing hypodermis. | Paper_evidence | WBPaper00035152 | |||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 19 Sep 2011 00:00:00 | ||||||
Automated_description | Predicted to enable glycosyltransferase activity. Predicted to be located in membrane. Expressed in seam cell. Used to study bacterial infectious disease. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:104 | Homo sapiens | Paper_evidence | WBPaper00035152 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 13 Mar 2023 00:00:00 | ||||||
Disease_relevance | C. elegans is being used as a model system to identify and study the genes required for the formation of bacterial biofilms in the host; the inherent resistance of biofilms to antimicrobial agents like phagocytes, antibiotics etc, are the root cause of chronic bacterial infections; the bah genes in elegans, bah-1, bah-2 and bah-3 are required for infection of elegans by biofilm producing bacteria Yersinia pestis and Yersinia pseudotuberculosis, which bind to the C. elegans surface, predominantly on the head. | Homo sapiens | Paper_evidence | WBPaper00006215 | |||
WBPaper00035152 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 19 Sep 2011 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000010 | ||||||
Molecular_info | Corresponding_CDS | ZK1025.7 | |||||
Corresponding_transcript | ZK1025.7.1 | ||||||
Other_sequence | CR08419 | ||||||
CRC03784_1 | |||||||
Associated_feature | WBsf218537 | ||||||
WBsf218538 | |||||||
Experimental_info | RNAi_result | WBRNAi00059046 | Inferred_automatically | RNAi_primary | |||
WBRNAi00082255 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059047 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00004903 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00004905 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00082265 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr12811 | ||||||
Expr1011822 | |||||||
Expr1040381 | |||||||
Expr1162477 | |||||||
Expr2009528 | |||||||
Expr2027765 | |||||||
Drives_construct (3) | |||||||
Construct_product | WBCnstr00022882 | ||||||
WBCnstr00022883 | |||||||
WBCnstr00023201 | |||||||
Microarray_results (13) | |||||||
Expression_cluster (174) | |||||||
Interaction (178) | |||||||
Map_info | Map | I | Position | 8.73905 | Error | 0.018869 | |
Positive | Positive_clone | ZK1025 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Pos_neg_data | 10949 | |||||
10950 | |||||||
10951 | |||||||
Reference | WBPaper00029153 | ||||||
WBPaper00031925 | |||||||
WBPaper00035152 | |||||||
WBPaper00039104 | |||||||
WBPaper00048269 | |||||||
WBPaper00051834 | |||||||
WBPaper00065106 | |||||||
Method | Gene |