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WormBase Tree Display for Gene: WBGene00022631

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Name Class

WBGene00022631SMapS_parentSequenceZC581
IdentityVersion3
NameCGC_namenekl-2Person_evidenceWBPerson353
Sequence_nameZC581.1
Molecular_nameZC581.1
ZC581.1.1
CE15235
Other_namephi-35Person_evidenceWBPerson2582
CELE_ZC581.1Accession_evidenceNDBBX284601
Public_namenekl-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:06WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
217 Mar 2005 13:54:35WBPerson2970Name_changeOther_namephi-35
316 Feb 2007 14:39:36WBPerson2970Name_changeCGC_namenekl-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnekl
Allele (30)
StrainWBStrain00036830
WBStrain00036864
WBStrain00037462
RNASeq_FPKM (74)
GO_annotation (16)
Ortholog (30)
ParalogWBGene00015376Caenorhabditis elegansFrom_analysisPanther
WBGene00021461Caenorhabditis elegansFrom_analysisTreeFam
WormBase-Compara
WBGene00008956Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00013694Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00017033Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00020324Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionnekl-2 encodes a putative serine/threonine protein kinase orthologousto Aspergillus nidulans nimA and human NEK8 (OMIM:609799), andparalogous to C. elegans D1044.3, D1044.8, F19H6.1, and Y39G10AR.3;nekl-2 interacts with two or more components of the EGF/RAS signallingpathway, and is required for such signalling in vulval development.Paper_evidenceWBPaper00027756
WBPaper00028846
Curator_confirmedWBPerson567
Date_last_updated13 Dec 2006 00:00:00
Automated_descriptionPredicted to enable ion binding activity and protein kinase activity. Involved in molting cycle and positive regulation of endocytosis. Predicted to be located in cytoplasm. Expressed in hyp7 syncytium. Is an ortholog of human NEK3 (NIMA related kinase 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSZC581.1
Corresponding_transcriptZC581.1.1
Other_sequence (24)
Associated_featureWBsf643393
WBsf217871
WBsf217872
Experimental_infoRNAi_result (26)
Expr_patternExpr12111
Expr15100
Expr1023880
Expr1039999
Expr1162440
Expr2013953
Expr2032192
Drives_constructWBCnstr00020196
WBCnstr00024095
Construct_productWBCnstr00020196
WBCnstr00024095
Microarray_results (19)
Expression_cluster (128)
Interaction (32)
Map_infoMapIPosition1.28369Error0.002544
PositivePositive_cloneZC581Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (20)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene