WormBase Tree Display for Gene: WBGene00021888
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| WBGene00021888 | SMap | S_parent | Sequence | Y54G2A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | manf-1 | Person_evidence | WBPerson10688 | |||||
| Sequence_name | Y54G2A.23 | ||||||||
| Molecular_name | Y54G2A.23 | ||||||||
| Y54G2A.23.1 | |||||||||
| CE30049 | |||||||||
| Other_name | Y54G2A.o | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y54G2A.23 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | manf-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 27 Jun 2017 00:34:54 | WBPerson2970 | Name_change | CGC_name | manf-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | manf | ||||||||
| Allele (23) | |||||||||
| Possibly_affected_by | WBVar02153024 | ||||||||
| WBVar02153253 | |||||||||
| Strain | WBStrain00047535 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Contained_in_operon | CEOP4072 | ||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | Y54G2A.23 is orthologous to the human genes CDNF (Conserved Dopamine Neurotrophic Factor), also known as ARMETL1 (Arginine-Rich Protein Mutated In Early Stage Tumors-Like 1) and MANF (Mesencephalic Astrocyte-derived Neurotrophic Factor); CDNF is involved in the survival and function of dopaminergic neurons. | Paper_evidence | WBPaper00038491 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 01 Jun 2012 00:00:00 | ||||||||
| Automated_description | Enables sulfatide binding activity. Involved in developmental growth and regulation of response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum and extracellular space. Expressed in several structures, including anus; excretory gland cell; pharynx; rectal valve cell; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; carcinoma (multiple); and pancreatic cancer. Is an ortholog of human CDNF (cerebral dopamine neurotrophic factor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15461) | ||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15461) | ||||||
| DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15461) | ||||||
| DOID:0080855 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15461) | ||||||
| DOID:1749 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15461) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15461) | ||||||
| Disease_relevance | Mutations in human MANF (Mesencephalic Astrocyte-derived Neurotrophic Factor; orthologous to elegans Y54G2A.23) are associated with tumors of the lung, breast and prostate cancers. | Homo sapiens | Accession_evidence | OMIM | 601916 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 01 Jun 2012 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y54G2A.23 | |||||||
| Corresponding_transcript | Y54G2A.23.1 | ||||||||
| Other_sequence (49) | |||||||||
| Associated_feature | WBsf651686 | ||||||||
| WBsf981703 | |||||||||
| WBsf229852 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00057455 | Inferred_automatically | RNAi_primary | |||||
| Expr_pattern | Expr13625 | ||||||||
| Expr13873 | |||||||||
| Expr15209 | |||||||||
| Expr1026501 | |||||||||
| Expr1039612 | |||||||||
| Expr1160887 | |||||||||
| Expr2007939 | |||||||||
| Expr2026181 | |||||||||
| Drives_construct | WBCnstr00040222 | ||||||||
| Antibody | WBAntibody00002915 | ||||||||
| Microarray_results (15) | |||||||||
| Expression_cluster (97) | |||||||||
| Map_info | Map | IV | Position | -6.69417 | |||||
| Positive | Positive_clone | Y54G2A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00053758 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00055101 | |||||||||
| WBPaper00056823 | |||||||||
| WBPaper00059347 | |||||||||
| WBPaper00060970 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
