WormBase Tree Display for Gene: WBGene00019877
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| WBGene00019877 | SMap | S_parent | Sequence | R05D3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lmbr-1 | Author_evidence | WBPerson30888 | |||||
| WBPerson205 | |||||||||
| Sequence_name | R05D3.2 | ||||||||
| Molecular_name | R05D3.2a | ||||||||
| R05D3.2a.1 | |||||||||
| CE00281 | |||||||||
| R05D3.2b | |||||||||
| CE54571 | |||||||||
| R05D3.2b.1 | |||||||||
| Other_name | CELE_R05D3.2 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | lmbr-1 | ||||||||
| DB_info | Database | AceView | gene | 3J463 | |||||
| WormQTL | gene | WBGene00019877 | |||||||
| WormFlux | gene | WBGene00019877 | |||||||
| OMIM | disease | 174500 | |||||||
| 186200 | |||||||||
| 200500 | |||||||||
| gene | 605522 | ||||||||
| NDB | locus_tag | CELE_R05D3.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00019877|UniProtKB=P34535 | |||||||
| family | PTHR12625 | ||||||||
| NCBI | gene | 176182 | |||||||
| RefSeq | protein | NM_001424973.1 | |||||||
| NM_066446.7 | |||||||||
| SwissProt | UniProtAcc | P34535 | |||||||
| UniProt_GCRP | UniProtAcc | P34535 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:02 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 10 Jul 2023 23:47:10 | WBPerson51134 | Name_change | CGC_name | lmbr-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lmbr | ||||||||
| Allele (35) | |||||||||
| Strain | WBStrain00001312 | ||||||||
| WBStrain00001313 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00042890 | ||||||||
| 00042891 | |||||||||
| Contained_in_operon | CEOP3516 | ||||||||
| Ortholog (41) | |||||||||
| Structured_description | Concise_description | R05D3.2 is orthologous to the human gene, LMBR1 (Limb Region 1, Mouse, Homolog Of). | Paper_evidence | WBPaper00038491 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 29 May 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in bone development disease (multiple) and hypoplastic or aplastic tibia with polydactyly. Is an ortholog of human LMBR1 (limb development membrane protein 1) and LMBR1L (limb development membrane protein 1 like). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111818 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13243) | ||||
| DOID:0050603 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13243) | ||||||
| EFO:MONDO:0017425 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13243) | ||||||
| DOID:0111564 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13243) | ||||||
| DOID:0111350 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13243) | ||||||
| Disease_relevance | Mutations in the human gene LMBR1 (orthologous to elegans R05D3.2), also known as Limb region 1 protein homolog, are associated with limb malformations like Acheiropody, Polydactyly, Syndactyly, Triphalangeal thumb and Triphalangeal thumb-polysyndactyly syndromes; LMBR1 is the human ortholog of the mouse Lmbr1 gene and encodes a putative receptor. | Homo sapiens | Accession_evidence | OMIM | 200500 | ||||
| 174500 | |||||||||
| 186200 | |||||||||
| 605522 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 29 May 2012 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R05D3.2a | |||||||
| R05D3.2b | |||||||||
| Corresponding_transcript | R05D3.2a.1 | ||||||||
| R05D3.2b.1 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf993326 | ||||||||
| WBsf1015414 | |||||||||
| WBsf225401 | |||||||||
| WBsf225402 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00051277 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00034601 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005635 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017429 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram2066 | ||||||||
| Expr6458 | |||||||||
| Expr1027678 | |||||||||
| Expr1038622 | |||||||||
| Expr1154978 | |||||||||
| Expr2005390 | |||||||||
| Expr2023610 | |||||||||
| Drives_construct | WBCnstr00002205 | ||||||||
| WBCnstr00002206 | |||||||||
| WBCnstr00025528 | |||||||||
| Construct_product | WBCnstr00025528 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction | WBInteraction000231970 | ||||||||
| WBInteraction000347084 | |||||||||
| WBInteraction000356153 | |||||||||
| WBInteraction000392099 | |||||||||
| WBInteraction000392100 | |||||||||
| WBInteraction000392101 | |||||||||
| Map_info | Positive | Positive_clone | R05D3 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
| Interpolated_map_position | III | -0.276368 | |||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00055090 | |||||||||
| Method | Gene |
