WormBase Tree Display for Gene: WBGene00019627
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| WBGene00019627 | SMap | S_parent | Sequence | K10D2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | hira-1 | Person_evidence | WBPerson15197 | |||||
| Sequence_name | K10D2.1 | ||||||||
| Molecular_name | K10D2.1a | ||||||||
| K10D2.1a.1 | |||||||||
| CE43736 | |||||||||
| K10D2.1c | |||||||||
| CE52272 | |||||||||
| K10D2.1b | |||||||||
| K10D2.1c.1 | |||||||||
| Other_name | CELE_K10D2.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | hira-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:01 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 20 Apr 2009 10:11:45 | WBPerson1867 | Event | Split_into | WBGene00189952 | ||||
| 3 | 01 Aug 2017 12:58:54 | WBPerson2970 | Name_change | CGC_name | hira-1 | ||||
| Split_into | WBGene00189952 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hira | ||||||||
| Allele (60) | |||||||||
| Strain | WBStrain00007462 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (40) | |||||||||
| Structured_description | Automated_description | Predicted to contribute to nucleosome binding activity. Predicted to be involved in chromatin remodeling. Predicted to be located in nucleus. Predicted to be part of HIR complex. Expressed widely. Used to study chromosome 22q11.2 deletion syndrome, distal. Is an ortholog of human HIRA (histone cell cycle regulator). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:6419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4916) | |||||
| Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including HIRA (histone cell cycle regulator); the C. elegans ortholog hira-1 is an essential gene, as knock-outs are embryonic lethal; hira-1 provides a potential model system to study genes involved in 22q11.2DS. | Homo sapiens | Paper_evidence | WBPaper00047004 | |||||
| Accession_evidence | OMIM | 611867 | |||||||
| 600237 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 16 Sep 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000365 | ||||||||
| Molecular_info | Corresponding_CDS | K10D2.1a | |||||||
| K10D2.1c | |||||||||
| Corresponding_CDS_history | K10D2.1a:wp202 | ||||||||
| K10D2.1b:wp153 | |||||||||
| K10D2.1b:wp261 | |||||||||
| Corresponding_transcript | K10D2.1b | ||||||||
| K10D2.1a.1 | |||||||||
| K10D2.1c.1 | |||||||||
| Other_sequence | Dviv_isotig12354 | ||||||||
| Dviv_isotig12356 | |||||||||
| CR03958 | |||||||||
| Dviv_isotig12357 | |||||||||
| CR07219 | |||||||||
| CRC04159_1 | |||||||||
| CJC02527_1 | |||||||||
| CRC08514_1 | |||||||||
| Oden_isotig24042 | |||||||||
| Dviv_isotig12355 | |||||||||
| Associated_feature | WBsf658907 | ||||||||
| WBsf658908 | |||||||||
| WBsf658909 | |||||||||
| WBsf658910 | |||||||||
| WBsf658911 | |||||||||
| WBsf992328 | |||||||||
| WBsf224877 | |||||||||
| WBsf224878 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr15090 | ||||||||
| Expr1015213 | |||||||||
| Expr1038475 | |||||||||
| Expr1154232 | |||||||||
| Expr2005030 | |||||||||
| Expr2023249 | |||||||||
| Drives_construct | WBCnstr00025717 | ||||||||
| WBCnstr00042001 | |||||||||
| Construct_product | WBCnstr00025717 | ||||||||
| WBCnstr00042001 | |||||||||
| Regulate_expr_cluster | WBPaper00059739:hira-1(gk835598)_downregulated_adult | ||||||||
| WBPaper00059739:hira-1(gk835598)_downregulated_L1 | |||||||||
| WBPaper00059739:hira-1(gk835598)_downregulated_L4 | |||||||||
| WBPaper00059739:hira-1(gk835598)_upregulated_adult | |||||||||
| WBPaper00059739:hira-1(gk835598)_upregulated_L1 | |||||||||
| WBPaper00059739:hira-1(gk835598)_upregulated_L4 | |||||||||
| Antibody | WBAntibody00002908 | ||||||||
| WBAntibody00002909 | |||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (109) | |||||||||
| Interaction (36) | |||||||||
| Map_info | Map | III | Position | -2.03197 | |||||
| Positive | Positive_clone | K10D2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00015268 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00057644 | |||||||||
| WBPaper00059739 | |||||||||
| WBPaper00065308 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
