WormBase Tree Display for Gene: WBGene00018819
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| WBGene00018819 | SMap | S_parent | Sequence | F54D12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 4 | |||||||
| Name | CGC_name | rog-1 | Paper_evidence | WBPaper00029182 | |||||
| Sequence_name | F54D12.6 | ||||||||
| Molecular_name | F54D12.6a | ||||||||
| F54D12.6a.1 | |||||||||
| CE45646 | |||||||||
| F54D12.6b | |||||||||
| CE47739 | |||||||||
| F54D12.6b.1 | |||||||||
| Other_name | eom-1 | Person_evidence | WBPerson1816 | ||||||
| WBPerson555 | |||||||||
| F54D12.d | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| F54D12.e | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_F54D12.6 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | rog-1 | ||||||||
| DB_info | Database | AceView | gene | 2B662 | |||||
| WormQTL | gene | WBGene00018819 | |||||||
| WormFlux | gene | WBGene00018819 | |||||||
| NDB | locus_tag | CELE_F54D12.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00018819|UniProtKB=E6N0V1 | |||||||
| family | PTHR21258 | ||||||||
| NCBI | gene | 186242 | |||||||
| RefSeq | protein | NM_001276728.3 | |||||||
| NM_061557.3 | |||||||||
| TrEMBL | UniProtAcc | E6N0V1 | |||||||
| I7LFE2 | |||||||||
| UniProt_GCRP | UniProtAcc | E6N0V1 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 26 Mar 2007 13:57:19 | WBPerson2970 | Name_change | CGC_name | rog-1 | ||||
| 3 | 20 Dec 2010 16:35:22 | WBPerson1849 | Event | Acquires_merge | WBGene00018818 | ||||
| 4 | 06 May 2011 10:58:08 | WBPerson2970 | Name_change | Other_name | eom-1 | ||||
| Acquires_merge | WBGene00018818 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rog | ||||||||
| Allele (183) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00008329 | ||||||||
| 00008330 | |||||||||
| 00008331 | |||||||||
| 00008332 | |||||||||
| 00008333 | |||||||||
| Ortholog (42) | |||||||||
| Structured_description | Concise_description | rog-1 encodes a protein with an insulin receptor substrate-1 (IRS-type) phosphotyrosine-binding (PTB) domain that is required for the progression from pachytene to diakinesis in meiosis; rog-1 is primarily transcribed in germ cells, and this expression is required for oocyte development; ROG-1 is orthologous to human FRS2 (OMIM:607743) and FRS3 (OMIM:607744); rog-1(tm1031) mutant oocytes fail to progress from pachytene to diakinesis, a phenotype reminiscent of let-60 or mpk-1 mutant oocytes, and rog-1(tm1031) gonads lack phosphorylated MPK-1; rog-1(tm1031) and rog-1(RNAi) hermaphrodites show reduced brood sizes and increased embryonic lethality, with rog-1(tm1031) being more phenotypically severe than rog-1(RNAi); rog-1(tm1031) germ cell, brood size, and MPK-1 phosphorylation phenotypes are suppressed by the gain-of-function mutations let-60(n1046) or let-60(ga89ts); during meiosis, ROG-1 may function as an adaptor downstream of LET-23 and upstream of LET-60. | Paper_evidence | WBPaper00029182 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 26 Nov 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable fibroblast growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be located in cytoplasm. Expressed in germ line. Human ortholog(s) of this gene implicated in renal cell carcinoma. Is an ortholog of human FRS3 (fibroblast growth factor receptor substrate 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16971) | ||||
| Molecular_info | Corresponding_CDS | F54D12.6a | |||||||
| F54D12.6b | |||||||||
| Corresponding_CDS_history | F54D12.6:wp222 | ||||||||
| Corresponding_transcript | F54D12.6a.1 | ||||||||
| F54D12.6b.1 | |||||||||
| Other_sequence | CR03616 | ||||||||
| CBC12440_1 | |||||||||
| CRC04200_1 | |||||||||
| Associated_feature | WBsf665354 | ||||||||
| WBsf716970 | |||||||||
| WBsf986668 | |||||||||
| WBsf986669 | |||||||||
| WBsf986670 | |||||||||
| WBsf986671 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr4839 | ||||||||
| Expr1011923 | |||||||||
| Expr1038117 | |||||||||
| Expr1152104 | |||||||||
| Expr2015402 | |||||||||
| Expr2033636 | |||||||||
| Microarray_results (50) | |||||||||
| Expression_cluster (128) | |||||||||
| Interaction (48) | |||||||||
| Map_info | Map | II | Position | -15.4736 | Error | 0.004529 | |||
| Positive | Positive_clone | F54D12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00025996 | ||||||||
| WBPaper00027928 | |||||||||
| WBPaper00029182 | |||||||||
| WBPaper00036021 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
