WormBase Tree Display for Gene: WBGene00017557
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| WBGene00017557 | SMap | S_parent | Sequence | F18A12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | nep-11 | Person_evidence | WBPerson260 | |||||
| Sequence_name | F18A12.8 | ||||||||
| Molecular_name | F18A12.8a | ||||||||
| F18A12.8a.1 | |||||||||
| CE23669 | |||||||||
| F18A12.8b | |||||||||
| CE32629 | |||||||||
| F18A12.8b.1 | |||||||||
| Other_name | CELE_F18A12.8 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | nep-11 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:59 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 10 Feb 2012 15:49:10 | WBPerson2970 | Name_change | CGC_name | nep-11 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nep | ||||||||
| Allele (122) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (61) | |||||||||
| Paralog (24) | |||||||||
| Structured_description | Concise_description | F18A12.8 encodes two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.8A is closely paralogous to ZK20.6, and orthologous to CG9761 in Drosophila melanogaster; F18A12.8 is homologous, and possibly orthologous, to human ECE1 (OMIM:600423; mutation leads to Hirschsprung disease, cardiac defects, and autonomic dysfunction); more generally, F18A12.8A falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes). | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00004584 | |||||||||
| WBPaper00013276 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); congestive heart failure; and dilated cardiomyopathy. Is an ortholog of human ECE1 (endothelin converting enzyme 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||
| DOID:6000 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| DOID:10825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| DOID:5844 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3146) | ||||||
| Molecular_info | Corresponding_CDS | F18A12.8a | |||||||
| F18A12.8b | |||||||||
| Corresponding_transcript | F18A12.8a.1 | ||||||||
| F18A12.8b.1 | |||||||||
| Other_sequence (27) | |||||||||
| Associated_feature | WBsf222853 | ||||||||
| WBsf222854 | |||||||||
| WBsf222855 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00031096 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00044929 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00013496 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089044 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1011660 | ||||||||
| Expr1037538 | |||||||||
| Expr1148895 | |||||||||
| Expr2013957 | |||||||||
| Expr2032196 | |||||||||
| Drives_construct | WBCnstr00027207 | ||||||||
| Construct_product | WBCnstr00027207 | ||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (13) | |||||||||
| Map_info | Map | II | Position | -6.30779 | |||||
| Positive | Positive_clone | F18A12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00019195 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
