WormBase Tree Display for Gene: WBGene00017393

WBGene00017393 SMap: S_parent: Sequence: F12A10
  Identity: Version: 2
    Name: CGC_name: nep-5 Person_evidence: WBPerson260
      Sequence_name: F12A10.4
      Molecular_name: F12A10.4
        F12A10.4.1
        CE54011
      Other_name: CELE_F12A10.4 Accession_evidence: NDB BX284602
      Public_name: nep-5
    DB_info: Database: AceView gene 2F779
        WormQTL gene WBGene00017393
        WormFlux gene WBGene00017393
        NDB locus_tag CELE_F12A10.4
        Panther gene CAEEL|WormBase=WBGene00017393|UniProtKB=Q09946
          family PTHR11733
        NCBI gene 173933
        RefSeq protein NM_001377801.1
        TrEMBL UniProtAcc Q09946
        UniProt_GCRP UniProtAcc Q09946
        OMIM gene 605896
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:58 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 10 Feb 2012 15:49:10 WBPerson2970 Name_change: CGC_name: nep-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nep
    Allele (39)
    Strain: WBStrain00033134
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (94)
    Paralog (24)
    Structured_description: Concise_description: F12A10.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F12A10.4 has no clear orthologs in other organisms. Paper_evidence: WBPaper00004584
            WBPaper00013276
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Is an ortholog of human ECEL1 (endothelin converting enzyme like 1) and KEL (Kell metallo-endopeptidase (Kell blood group)). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111594 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3147)
  Molecular_info: Corresponding_CDS: F12A10.4
    Corresponding_CDS_history: F12A10.4:wp228
      F12A10.4:wp274
    Corresponding_transcript: F12A10.4.1
    Other_sequence: CR03396
      CRC04115_1
    Associated_feature: WBsf987896
      WBsf1012233
  Experimental_info: RNAi_result: WBRNAi00013155 Inferred_automatically: RNAi_primary
      WBRNAi00044425 Inferred_automatically: RNAi_primary
      WBRNAi00001260 Inferred_automatically: RNAi_primary
      WBRNAi00089036 Inferred_automatically: RNAi_primary
      WBRNAi00030849 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1016375
      Expr1148370
      Expr2013973
    Drives_construct: WBCnstr00027331
    Construct_product: WBCnstr00027331
    Microarray_results (18)
    Expression_cluster (105)
    Interaction: WBInteraction000426992
      WBInteraction000503131
  Map_info: Map: II Position: -1.27871
    Positive: Positive_clone: F12A10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00011735
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene