WormBase Tree Display for Gene: WBGene00012767
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WBGene00012767 | SMap | S_parent | Sequence | Y41E3 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | fcd-2 | Paper_evidence | WBPaper00028405 | |||
Person_evidence | WBPerson1839 | ||||||
Sequence_name | Y41E3.9 | ||||||
Molecular_name | Y41E3.9a | ||||||
Y41E3.9a.1 | |||||||
CE40581 | |||||||
Y41E3.9b | |||||||
CE44662 | |||||||
Y41E3.9c | |||||||
CE45681 | |||||||
Y41E3.9b.1 | |||||||
Y41E3.9c.1 | |||||||
Other_name | CELE_Y41E3.9 | Accession_evidence | NDB | BX284604 | |||
Public_name | fcd-2 | ||||||
DB_info | Database (11) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | fcd | ||||||
Allele (247) | |||||||
Strain | WBStrain00028632 | ||||||
WBStrain00031832 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (12) | |||||||
Contained_in_operon | CEOP4581 | ||||||
CEOP4662 | |||||||
Ortholog (42) | |||||||
Structured_description | Concise_description | fcd-2 encodes an ortholog of the human gene FANCD2 (mutated in Fanconianemia, OMIM:227646) that is strongly required for resistance to DNAinterstrand crosslinking (ICL) agents, but not to ionizing radiation (IR);fcd-2 mutants are viable and dispensable for resistance to IR, meioticrecombination, and S-phase checkpoint activation, but are hypersensitiveto ICL agents; like its human ortholog, FCD-2 is monoubiquitylated andrecruited to chromosomal foci after ICL but not IR; transgenic expresssionof the FANCD2 gene in mutant FA-D2 cells rescues their abnormalsensitivity to mitomycin C, an agent that cross-links strands of DNA. | Paper_evidence (4) | ||||
Curator_confirmed | WBPerson1823 | ||||||
WBPerson567 | |||||||
Date_last_updated | 06 Sep 2006 00:00:00 | ||||||
Automated_description | Predicted to enable DNA polymerase binding activity. Involved in nucleotide-excision repair and regulation of DNA-templated DNA replication. Located in nucleus. Expressed in germ line. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group D2; breast cancer; and skin melanoma. Is an ortholog of human FANCD2 (FA complementation group D2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:13636 | Homo sapiens | Paper_evidence | WBPaper00036433 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 26 Jan 2021 00:00:00 | ||||||
Potential_model | DOID:0111083 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3585) | |||
DOID:13636 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3585) | ||||
DOID:8923 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3585) | ||||
DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3585) | ||||
Models_disease_asserted | WBDOannot00000494 | ||||||
WBDOannot00000846 | |||||||
Molecular_info | Corresponding_CDS | Y41E3.9a | |||||
Y41E3.9b | |||||||
Y41E3.9c | |||||||
Corresponding_CDS_history | Y41E3.9:wp162 | ||||||
Y41E3.9:wp167 | |||||||
Corresponding_transcript | Y41E3.9a.1 | ||||||
Y41E3.9b.1 | |||||||
Y41E3.9c.1 | |||||||
Other_sequence | CBC07468_1 | ||||||
EL889667.1 | |||||||
MCC01007_1 | |||||||
MH07475 | |||||||
EL887798.1 | |||||||
BMC12225_1 | |||||||
MHC09449_1 | |||||||
EL889269.1 | |||||||
Associated_feature | WBsf646572 | ||||||
WBsf660953 | |||||||
WBsf660954 | |||||||
WBsf998672 | |||||||
WBsf998673 | |||||||
WBsf998674 | |||||||
WBsf1018720 | |||||||
WBsf1018721 | |||||||
WBsf1018722 | |||||||
WBsf229550 | |||||||
Experimental_info | RNAi_result (11) | ||||||
Expr_pattern | Expr8878 | ||||||
Expr1023457 | |||||||
Expr1035649 | |||||||
Expr1159900 | |||||||
Expr2011741 | |||||||
Expr2029979 | |||||||
Antibody | WBAntibody00001135 | ||||||
WBAntibody00001136 | |||||||
WBAntibody00001348 | |||||||
WBAntibody00002096 | |||||||
Microarray_results (24) | |||||||
Expression_cluster (130) | |||||||
Interaction | WBInteraction000032185 | ||||||
WBInteraction000052805 | |||||||
WBInteraction000249936 | |||||||
WBInteraction000540676 | |||||||
Map_info | Map | IV | Position | 12.8155 | Error | 0.001811 | |
Positive | Positive_clone | Y41E3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (29) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |