WormBase Tree Display for Gene: WBGene00009372
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WBGene00009372 | SMap | S_parent | Sequence | F34D10 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | evl | ||||||
Allele (68) | |||||||
Legacy_information | [C.elegansII] ar117 : everted vulva, sterile; no L4 vulval invagination; abnormal uterus; distal germline abnormal, no sperm or oocytes. NA1. [Seydoux et al., 1993] | ||||||
Strain | WBStrain00008015 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (14) | |||||||
Ortholog (36) | |||||||
Structured_description | Automated_description | Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Located in nucleus. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Is an ortholog of human CDC45 (cell division cycle 45). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 20 Sep 2018 00:00:00 | ||||||
Potential_model | DOID:0080518 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1739) | |||
Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including CDC45; C. elegans CDC45/evl-18 is involved in DNA replication initiation as RNAi depletion of evl-18 affects DNA replication and delays S phase; evl-18 knock-down phenotypes include reduced brood size, early embryo sister chromatid segregration defects, and sperm development and sterility defects; evl-18 provides a potential model system to study genes involved in 22q11.2DS. | Homo sapiens | Paper_evidence | WBPaper00047004 | |||
WBPaper00040279 | |||||||
WBPaper00047062 | |||||||
Accession_evidence | OMIM | 611867 | |||||
603465 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 16 Sep 2015 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000368 | ||||||
Molecular_info | Corresponding_CDS | F34D10.2 | |||||
Corresponding_CDS_history | F34D10.2:wp179 | ||||||
Corresponding_transcript | F34D10.2.1 | ||||||
Other_sequence (13) | |||||||
Associated_feature | WBsf650927 | ||||||
WBsf666681 | |||||||
WBsf666682 | |||||||
WBsf991883 | |||||||
WBsf991884 | |||||||
WBsf226385 | |||||||
WBsf226386 | |||||||
WBsf226387 | |||||||
Experimental_info | RNAi_result (16) | ||||||
Expr_pattern | Expr12321 | ||||||
Expr1012133 | |||||||
Expr1034106 | |||||||
Expr1150133 | |||||||
Expr2011388 | |||||||
Expr2029624 | |||||||
Drives_construct | WBCnstr00032243 | ||||||
Construct_product | WBCnstr00032243 | ||||||
Antibody | WBAntibody00002758 | ||||||
Microarray_results (13) | |||||||
Expression_cluster (94) | |||||||
Interaction (179) | |||||||
Map_info | Positive | Positive_clone | F34D10 | Inferred_automatically | From sequence, transcript, pseudogene data | ||
Mapping_data | Multi_point | 3473 | |||||
Interpolated_map_position | III | -4.30176 | |||||
Reference | WBPaper00001738 | ||||||
WBPaper00015476 | |||||||
WBPaper00038491 | |||||||
WBPaper00040279 | |||||||
WBPaper00044861 | |||||||
WBPaper00049197 | |||||||
WBPaper00055090 | |||||||
WBPaper00056327 | |||||||
WBPaper00065080 | |||||||
WBPaper00066002 | |||||||
Method | Gene |