WormBase Tree Display for Gene: WBGene00008805
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WBGene00008805 | SMap | S_parent | Sequence | F14F3 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | git-1 | Person_evidence | WBPerson3660 | |||||
WBPerson855 | |||||||||
Sequence_name | F14F3.2 | ||||||||
Molecular_name | F14F3.2 | ||||||||
F14F3.2.1 | |||||||||
CE31478 | |||||||||
Other_name | CELE_F14F3.2 | Accession_evidence | NDB | BX284606 | |||||
Public_name | git-1 | ||||||||
DB_info | Database | AceView | gene | XL145 | |||||
WormQTL | gene | WBGene00008805 | |||||||
WormFlux | gene | WBGene00008805 | |||||||
NDB | locus_tag | CELE_F14F3.2 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00008805|UniProtKB=Q19467 | |||||||
family | PTHR46097 | ||||||||
NCBI | gene | 181253 | |||||||
RefSeq | protein | NM_077360.9 | |||||||
TREEFAM | TREEFAM_ID | TF317762 | |||||||
TrEMBL | UniProtAcc | Q19467 | |||||||
UniProt_GCRP | UniProtAcc | Q19467 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
2 | 15 Dec 2006 15:03:44 | WBPerson1847 | Name_change | CGC_name | git-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | git | ||||||||
Allele (41) | |||||||||
Strain | WBStrain00003411 | ||||||||
WBStrain00032236 | |||||||||
WBStrain00026591 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (16) | |||||||||
Ortholog (51) | |||||||||
Paralog | WBGene00000566 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
WormBase-Compara | |||||||||
WBGene00000565 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00010500 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00012359 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00017217 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00017760 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | git-1 encodes a scafolding protein that forms a highly conserved signaling complex with PIX-1 and PAK, and interacts with Rac/CDC42 GTPases; git-1 is orthologous to mammalian git1(OMIM: 608434); GIT-1 work together with PIX-1 and PAK-1 independently of RAC/CDC-42 GTPases to control DTC migration during gonad morphogenesis; in epithelial morphogenesis GIT-1, PIX-1 and PAK-1 together regulate intermediate-filament phosphorylation and CeHD biogenesis; Tension exerted by adjacent muscles or externally exerted mechanical pressure maintains GIT-1 at hemidesmosome and stimulates PAK-1 activity through PIX-1 and Rac; GIT-1 is expressed in CeHDs and migrating DTCs. | Paper_evidence | WBPaper00032371 | |||||
WBPaper00038193 | |||||||||
Curator_confirmed | WBPerson12884 | ||||||||
Date_last_updated | 12 Jul 2011 00:00:00 | ||||||||
Automated_description | Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in gonad morphogenesis and inductive cell migration. Located in hemidesmosome and presynaptic active zone. Human ortholog(s) of this gene implicated in Huntington's disease and attention deficit hyperactivity disorder. Is an ortholog of human GIT2 (GIT ArfGAP 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4272) | ||||
DOID:1094 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4272) | ||||||
Molecular_info | Corresponding_CDS | F14F3.2 | |||||||
Corresponding_CDS_history | F14F3.2:wp83 | ||||||||
Corresponding_transcript | F14F3.2.1 | ||||||||
Other_sequence | Dviv_isotig33964 | ||||||||
Associated_feature | WBsf648481 | ||||||||
WBsf663252 | |||||||||
WBsf1006734 | |||||||||
WBsf1006735 | |||||||||
WBsf236290 | |||||||||
Experimental_info | RNAi_result (11) | ||||||||
Expr_pattern | Chronogram359 | ||||||||
Expr4961 | |||||||||
Expr4969 | |||||||||
Expr5759 | |||||||||
Expr11072 | |||||||||
Expr1017041 | |||||||||
Expr1033842 | |||||||||
Expr1148582 | |||||||||
Expr2012042 | |||||||||
Expr2030278 | |||||||||
Drives_construct | WBCnstr00003878 | ||||||||
WBCnstr00008106 | |||||||||
WBCnstr00032671 | |||||||||
Construct_product | WBCnstr00008106 | ||||||||
WBCnstr00032671 | |||||||||
Microarray_results (20) | |||||||||
Expression_cluster (111) | |||||||||
Interaction (43) | |||||||||
Map_info | Map | X | Position | 2.22518 | Error | 0.000173 | |||
Positive | Positive_clone | F14F3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (18) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |