WormBase Tree Display for Gene: WBGene00007118
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| WBGene00007118 | SMap | S_parent | Sequence | B0240 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | npp-22 | Paper_evidence | WBPaper00027221 | |||||
| Person_evidence | WBPerson1780 | ||||||||
| Sequence_name | B0240.4 | ||||||||
| Molecular_name | B0240.4 | ||||||||
| B0240.4.1 | |||||||||
| CE31866 | |||||||||
| Other_name | ndc-1 | Paper_evidence | WBPaper00027632 | ||||||
| NDC1 | Paper_evidence | WBPaper00027221 | |||||||
| CELE_B0240.4 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | npp-22 | ||||||||
| DB_info | Database | AceView | gene | 5M212 | |||||
| WormQTL | gene | WBGene00007118 | |||||||
| WormFlux | gene | WBGene00007118 | |||||||
| NDB | locus_tag | CELE_B0240.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00007118|UniProtKB=Q8I4N3 | |||||||
| family | PTHR13269 | ||||||||
| NCBI | gene | 179607 | |||||||
| RefSeq | protein | NM_073561.8 | |||||||
| SwissProt | UniProtAcc | Q8I4N3 | |||||||
| TREEFAM | TREEFAM_ID | TF318655 | |||||||
| UniProt_GCRP | UniProtAcc | Q8I4N3 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:47 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 25 Apr 2006 16:12:14 | WBPerson2970 | Name_change | CGC_name | npp-22 | ||||
| 3 | 28 Jan 2008 15:22:37 | WBPerson2970 | Name_change | Other_name | ndc-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | npp | ||||||||
| Allele (48) | |||||||||
| Strain | WBStrain00054787 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00007117 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Structured_description | Concise_description | npp-22 encodes a nuclear pore complex protein that inhibits DHC-1 in vivo, and that is required for normal nuclear pore complexes; NPP-22 is orthologous to human TMEM48 and budding yeast NDC1; npp-22(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that NPP-22 negatively regulates dynein; npp-22(tm1845) mutants have rudimentary nuclear pore complexes, and are poorly viable; NPP-22 has an N-terminal domain predicted to contain five transmembrane helices; in early embryos, NPP-22 is associated with nuclear envelopes and the vicinity of mitotic centrosomes; npp-22 is required for normally large embryonic pronuclei in mass RNAi assays. | Paper_evidence | WBPaper00025054 | |||||
| WBPaper00027221 | |||||||||
| WBPaper00027632 | |||||||||
| WBPaper00030897 | |||||||||
| WBPaper00030919 | |||||||||
| WBPaper00030920 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 26 Aug 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in nuclear pore organization. Part of nuclear pore. Is an ortholog of human NDC1 (NDC1 transmembrane nucleoporin). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | B0240.4 | |||||||
| Corresponding_transcript | B0240.4.1 | ||||||||
| Other_sequence (13) | |||||||||
| Associated_feature | WBsf653149 | ||||||||
| WBsf669411 | |||||||||
| WBsf669412 | |||||||||
| WBsf669413 | |||||||||
| WBsf1001429 | |||||||||
| WBsf1020494 | |||||||||
| WBsf234573 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00008157 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00038786 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009625 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00117199 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4802 | ||||||||
| Expr7835 | |||||||||
| Expr1027006 | |||||||||
| Expr1033063 | |||||||||
| Expr1142994 | |||||||||
| Expr2014382 | |||||||||
| Expr2032623 | |||||||||
| Drives_construct | WBCnstr00033982 | ||||||||
| Construct_product | WBCnstr00001421 | ||||||||
| WBCnstr00033982 | |||||||||
| Antibody | WBAntibody00001093 | ||||||||
| WBAntibody00001094 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (136) | |||||||||
| Interaction | WBInteraction000008212 | ||||||||
| WBInteraction000008213 | |||||||||
| WBInteraction000008214 | |||||||||
| WBInteraction000523111 | |||||||||
| WBInteraction000524154 | |||||||||
| WBInteraction000524176 | |||||||||
| WBInteraction000570747 | |||||||||
| Map_info | Map | V | Position | 3.317 | Error | 0.003521 | |||
| Positive | Positive_clone | B0240 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00027221 | ||||||||
| WBPaper00027632 | |||||||||
| WBPaper00030897 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041255 | |||||||||
| WBPaper00047280 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00063941 | |||||||||
| WBPaper00064947 | |||||||||
| WBPaper00065742 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
