WormBase Tree Display for Gene: WBGene00006922
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WBGene00006922 | SMap | S_parent | Sequence | F08G12 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | vhl-1 | Person_evidence | WBPerson322 | |||||
Sequence_name | F08G12.4 | ||||||||
Molecular_name | F08G12.4 | ||||||||
F08G12.4.1 | |||||||||
CE03169 | |||||||||
Other_name | CELE_F08G12.4 | Accession_evidence | NDB | BX284606 | |||||
Public_name | vhl-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | vhl | ||||||||
Allele (18) | |||||||||
Strain | WBStrain00032096 | ||||||||
WBStrain00004655 | |||||||||
WBStrain00004677 | |||||||||
WBStrain00004678 | |||||||||
WBStrain00040827 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00063954 | ||||||||
00063955 | |||||||||
00063956 | |||||||||
00063957 | |||||||||
00063958 | |||||||||
00063959 | |||||||||
Ortholog (28) | |||||||||
Structured_description (2) | |||||||||
Disease_info | Experimental_model | DOID:4467 | Homo sapiens | Paper_evidence | WBPaper00061713 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 28 Jun 2022 00:00:00 | ||||||||
DOID:14175 | Homo sapiens | Paper_evidence | WBPaper00024375 | ||||||
WBPaper00036343 | |||||||||
Accession_evidence | OMIM | 193300 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson38202 | |||||||||
Date_last_updated | 02 Jul 2018 00:00:00 | ||||||||
Potential_model | DOID:0060474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) | |||||
DOID:0050771 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) | ||||||
DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) | ||||||
DOID:8432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) | ||||||
DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) | ||||||
DOID:3587 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) | ||||||
DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) | ||||||
DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) | ||||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) | ||||||
DOID:14175 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) | ||||||
Disease_relevance | The human ortholog VHL is mutated in von Hippel-Landau syndrome; VHL functions as a recessive tumor suppressor gene and is involved in oxygen-sensing, microtubule stability and cilia formation; studies in elegans indicate that: the ubiquitin ligase vhl-1, and its target, the hif-1 hypoxic response transcription factor, modulate life-span, vhl-1 and hif-1 mutants are longer-lived; hif-1 also protects against DNA-damage-induced germ cell apoptosis by antagonizing the function of CEP-1, the homolog of the tumour suppressor p53. | Homo sapiens | Paper_evidence | WBPaper00038373 | |||||
Accession_evidence | OMIM | 193300 | |||||||
608537 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 14 Feb 2012 00:00:00 | ||||||||
Models_disease_in_annotation | WBDOannot00000043 | ||||||||
Models_disease_asserted | WBDOannot00000597 | ||||||||
WBDOannot00000598 | |||||||||
WBDOannot00000600 | |||||||||
WBDOannot00000601 | |||||||||
WBDOannot00001276 | |||||||||
Molecular_info | Corresponding_CDS | F08G12.4 | |||||||
Corresponding_transcript | F08G12.4.1 | ||||||||
Associated_feature | WBsf648535 | ||||||||
WBsf1006969 | |||||||||
WBsf1006970 | |||||||||
WBsf1023853 | |||||||||
WBsf236370 | |||||||||
Experimental_info | RNAi_result (26) | ||||||||
Expr_pattern | Expr8170 | ||||||||
Expr15110 | |||||||||
Expr1019223 | |||||||||
Expr1032939 | |||||||||
Expr1148006 | |||||||||
Expr2017996 | |||||||||
Expr2036132 | |||||||||
Drives_construct | WBCnstr00013155 | ||||||||
WBCnstr00034097 | |||||||||
WBCnstr00042008 | |||||||||
Construct_product | WBCnstr00013155 | ||||||||
WBCnstr00034097 | |||||||||
Regulate_expr_cluster | WBPaper00024375:Up_N2_vs_vhl-1 | ||||||||
WBPaper00024375:Up_vhl-1_vs_hif-1_vhl-1 | |||||||||
Antibody | WBAntibody00000414 | ||||||||
Microarray_results (19) | |||||||||
Expression_cluster (78) | |||||||||
Interaction (35) | |||||||||
WBProcess | WBbiopr:00000096 | ||||||||
Map_info | Map | X | Position | 2.87713 | Error | 0.015196 | |||
Positive | Positive_clone | F08G12 | Inferred_automatically (2) | ||||||
Mapping_data | Multi_point | 4067 | |||||||
4442 | |||||||||
5397 | |||||||||
Reference (65) | |||||||||
Remark | Sequence connection from [Epstein ACR, Hodgkin JA, Ratcliffe PJ] | ||||||||
Method | Gene |