WormBase Tree Display for Gene: WBGene00006721
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WBGene00006721 | Evidence | Person_evidence | WBPerson2549 | ||||
---|---|---|---|---|---|---|---|
WBPerson6733 | |||||||
SMap | S_parent | Sequence | F46E10 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ubh | ||||||
Allele (25) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (21) | |||||||
Contained_in_operon | CEOP5120 | ||||||
Ortholog (39) | |||||||
Paralog (3) | |||||||
Structured_description | Concise_description | ubh-1 encodes a putative ubiquitin C-terminal hydrolase orthologous to human UCHL1, that catalyzes the hydrolysis of C-terminal ubiquitinyl esters; C. elegans has three ubiquitin C-terminal hydrolase orthologs-ubh-1, ubh-2 and ubh-3; studies indicate that the ubh genes maybe be involved in aging, as they play a role in cellular senescence. | Paper_evidence | WBPaper00027616 | |||
WBPaper00035660 | |||||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 15 Jul 2013 00:00:00 | ||||||
Automated_description | Enables deNEDDylase activity and deubiquitinase activity. Involved in negative regulation of dauer larval development; positive regulation of transforming growth factor beta receptor signaling pathway; and protein deneddylation. Predicted to be located in cytoplasm. Expressed in amphid neurons and intestinal cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia (multiple). Is an ortholog of human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035660 | ||
Accession_evidence | OMIM | 613643 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 15 Jul 2013 00:00:00 | ||||||
Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12513) | |||
DOID:0070455 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12513) | ||||
DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12513) | ||||
DOID:0112344 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12513) | ||||
Disease_relevance | Mutations in human ubiquitin C-terminal hydrolase L1 (UCHL1/PARK5; neuron specific) are associated with Parkinson''s disease (PD); UCH-L1 protects against protein aggregation disorders such as Alzheimer disease and PD and is part of the ubiquitin proteasome system; C. elegans is used as a model system to study the genetic interactions and molecular functions of PARK protein orthologs; studies that knock-down the ubh genes in elegans (ubh-1, ubh-2, ubh-3) indicate that they are involved in cellular senescence and thus aging. | Homo sapiens | Paper_evidence | WBPaper00027616 | |||
WBPaper00035660 | |||||||
Accession_evidence | OMIM | 613643 | |||||
191342 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 15 Jul 2013 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000209 | ||||||
Molecular_info | Corresponding_CDS | F46E10.8 | |||||
Corresponding_transcript | F46E10.8.1 | ||||||
Other_sequence (36) | |||||||
Associated_feature | WBsf669046 | ||||||
WBsf669047 | |||||||
WBsf669048 | |||||||
WBsf1000286 | |||||||
WBsf233815 | |||||||
Experimental_info | RNAi_result | WBRNAi00102982 | Inferred_automatically | RNAi_primary | |||
WBRNAi00102992 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00102972 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00015095 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00056335 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00094630 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00047527 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00076438 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr15525 | ||||||
Expr1027646 | |||||||
Expr1151366 | |||||||
Expr2017718 | |||||||
Expr2035856 | |||||||
Drives_construct | WBCnstr00042221 | ||||||
Construct_product | WBCnstr00042221 | ||||||
Microarray_results (17) | |||||||
Expression_cluster (153) | |||||||
Interaction (17) | |||||||
Map_info | Map | V | Position | -0.032234 | Error | 0.006589 | |
Positive | Positive_clone | F46E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00010020 | ||||||
WBPaper00025802 | |||||||
WBPaper00027616 | |||||||
WBPaper00030133 | |||||||
WBPaper00030965 | |||||||
WBPaper00038491 | |||||||
WBPaper00055090 | |||||||
WBPaper00060977 | |||||||
WBPaper00063803 | |||||||
WBPaper00064934 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |